Exacerbated neuronal ceroid lipofuscinosis phenotype in Cln1/5 double-knockout mice

Keyphrases

• Double Knockout Mice 100%
• CLN1 100%
• Neuronal Ceroid Lipofuscinosis 100%
• Mouse Model 18%
• CLN5 18%
• Induced Pluripotent Stem Cells (iPSCs) 9%
• Knock-in Mouse Model 9%
• Lipid Metabolism 9%
• Immune Response 9%
• Gene Expression Profiling 9%
• Cortex 9%
• Seizure 9%
• Neurodegenerative Diseases 9%
• Fibroblasts 9%
• Alpha-synuclein (α-syn) 9%
• Disease Mechanisms 9%
• Motor Dysfunction 9%
• Early Disease 9%
• Mouse Brain 9%
• Neuron Loss 9%
• Stem Cell-derived 9%
• Double Knockout 9%
• Myelination 9%
• Disease Manifestations 9%
• Glial Activation 9%
• Cortical Neurons 9%
• Thalamic 9%
• Storage Materials 9%
• Autofluorescent 9%
• Pathological Phenotype 9%
• Response Pathways 9%
• Pathological Analysis 9%
• Pathogenic Pathways 9%
• Plasma Phospholipids 9%
• Simultaneous Losses 9%
• Embryoid Body Formation 9%
• Cortical Demyelination 9%
• Phospholipid Transfer Protein Activity 9%
• Breeding Ratio 9%

Biochemistry, Genetics and Molecular Biology

• Knockout Mouse 100%
• Batten Disease 100%
• Neuronal Ceroid Lipofuscinosis 100%
• Mouse Model 40%
• Induced Pluripotent Stem Cell 20%
• Lipid Metabolism 20%
• Downregulation 20%
• Gene Expression Profiling 20%
• Immune Response 20%
• Embryoid Body 20%
• Myelination 20%
• Phospholipid Transfer Protein 20%
• Blood Plasma 20%
• Fibroblast 20%
• Synuclein 20%

Neuroscience

• Neuronal Ceroid Lipofuscinosis 100%
• Ceroid 100%
• Gene Expression 25%
• Neurodegenerative Disorder 25%
• Metabolic Pathway 25%
• Stem Cell 25%
• Synuclein 25%
• Stereotypic Movement Disorder 25%
• Myelinogenesis 25%
• Embryoid Body 25%
• Phospholipid Transfer Protein 25%
• Blood Plasma 25%
• Fibroblast 25%
• Mouse Brain 25%