Abstract
Reliable and robust peripheral nerve regeneration after a nerve injury and repair remains an elusive goal. A variety of strategies have been proposed to mitigate the effects of Wallerian degeneration (through molecular therapies), enhance axonal regeneration across the repair site (through electrical stimulation and gene therapy), and explore alternatives to suture coaptation (through the fusion of transected ends). Although most of these techniques are in their infancy, animal data and some clinical trials have demonstrated promise for improving the restoration of function after these devastating injuries.
Original language | English |
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Pages (from-to) | 695-701 |
Number of pages | 7 |
Journal | Journal of Hand Surgery |
Volume | 46 |
Issue number | 8 |
DOIs | |
State | Published - Aug 2021 |
Keywords
- Electrical stimulation
- SARM-1
- nerve regeneration
- peripheral nerve