Evolving Techniques in Peripheral Nerve Regeneration

Steven T. Lanier, J. Ryan Hill, Christopher J. Dy, David M. Brogan

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Reliable and robust peripheral nerve regeneration after a nerve injury and repair remains an elusive goal. A variety of strategies have been proposed to mitigate the effects of Wallerian degeneration (through molecular therapies), enhance axonal regeneration across the repair site (through electrical stimulation and gene therapy), and explore alternatives to suture coaptation (through the fusion of transected ends). Although most of these techniques are in their infancy, animal data and some clinical trials have demonstrated promise for improving the restoration of function after these devastating injuries.

Original languageEnglish
Pages (from-to)695-701
Number of pages7
JournalJournal of Hand Surgery
Volume46
Issue number8
DOIs
StatePublished - Aug 2021

Keywords

  • Electrical stimulation
  • SARM-1
  • nerve regeneration
  • peripheral nerve

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