Abstract
The rhesus macaque (Macaca mulatta) is an abundant primate species that diverged from the ancestors of Homo sapiens about 25 million years ago. Because they are genetically and physiologically similar to humans, rhesus monkeys are the most widely used nonhuman primate in basic and applied biomedical research. We determined the genome sequence of an Indian-origin Macaca mulatta female and compared the data with chimpanzees and humans to reveal the structure of ancestral primate genomes and to identify evidence for positive selection and lineage-specific expansions and contractions of gene families. A comparison of sequences from individual animals was used to investigate their underlying genetic diversity. The complete description of the macaque genome blueprint enhances the utility of this animal model for biomedical research and improves our understanding of the basic biology of the species.
| Original language | English |
|---|---|
| Pages (from-to) | 222-234 |
| Number of pages | 13 |
| Journal | Science |
| Volume | 316 |
| Issue number | 5822 |
| DOIs | |
| State | Published - Apr 13 2007 |
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Evolutionary and biomedical insights from the rhesus macaque genome. / Gibbs, Richard A.; Rogers, Jeffrey; Katze, Michael G.; Bumgarner, Roger; Weinstock, George M.; Mardis, Elaine R.; Remington, Karin A.; Strausberg, Robert L.; Venter, J. Craig; Wilson, Richard K.; Batzer, Mark A.; Bustamante, Carlos D.; Eichler, Evan E.; Hahn, Matthew W.; Hardison, Ross C.; Makova, Kateryna D.; Miller, Webb; Milosavljevic, Aleksandar; Palermo, Robert E.; Siepel, Adam; Sikela, James M.; Attaway, Tony; Bell, Stephanie; Bernard, Kelly E.; Buhay, Christian J.; Chandrabose, Mimi N.; Dao, Marvin; Davis, Clay; Delehaunty, Kimberly D.; Ding, Yan; Dinh, Huyen H.; Dugan-Rocha, Shannon; Fulton, Lucinda A.; Gabisi, Ramatu Ayiesha; Garner, Toni T.; Godfrey, Jennifer; Hawes, Alicia C.; Hernandez, Judith; Hines, Sandra; Holder, Michael; Hume, Jennifer; Jhangiani, Shalini N.; Joshi, Vandita; Khan, Ziad Mohid; Kirkness, Ewen F.; Cree, Andrew; Fowler, R. Gerald; Lee, Sandra; Lewis, Lora R.; Li, Zhangwan; Liu, Yih Shin; Moore, Stephanie M.; Muzny, Donna; Nazareth, Lynne V.; Dinh, Ngoc Ngo; Okwuonu, Geoffrey O.; Pai, Grace; Parker, David; Paul, Heidie A.; Pfannkoch, Cynthia; Pohl, Craig S.; Rogers, Yu Hui; Ruiz, San Juana; Sabo, Aniko; Santibanez, Jireh; Schneider, Brian W.; Smith, Scott M.; Sodergren, Erica; Svatek, Amanda F.; Utterback, Teresa R.; Vattathil, Selina; Warren, Wesley; White, Courtney Sherell; Chinwalla, Asif T.; Feng, Yucheng; Halpern, Aaron L.; Hillier, La Deana W.; Huang, Xiaoqiu; Minx, Pat; Nelson, Joanne O.; Pepin, Kymbertie H.; Qin, Xiang; Sutton, Granger G.; Venter, Eli; Walenz, Brian P.; Wallis, John W.; Worley, Kim C.; Yang, Shiaw Pyng; Jones, Steven M.; Marra, Marco A.; Rocchi, Mariano; Schein, Jacqueline E.; Baertsch, Robert; Clarke, Laura; Csürös, Miklós; Glasscock, Jarret; Harris, R. Alan; Havlak, Paul; Jackson, Andrew R.; Jiang, Huaiyang; Liu, Yue; Messina, David N.; Shen, Yufeng; Song, Henry Xing Zhi; Wylie, Todd; Zhang, Lan; Birney, Ewan; Han, Kyudong; Konkel, Miriam K.; Lee, Jungnam; Smit, Arian F.A.; Ullmer, Brygg; Wang, Hui; Xing, Jinchuan; Burhans, Richard; Cheng, Ze; Karro, John E.; Ma, Jian; Raney, Brian; She, Xinwei; Cox, Michael J.; Demuth, Jeffery P.; Dumas, Laura J.; Han, Sang Gook; Hopkins, Janet; Karimpour-Fard, Anis; Kim, Young H.; Pollack, Jonathan R.; Vinar, Tomas; Addo-Quaye, Charles; Degenhardt, Jeremiah; Denby, Alexandra; Hubisz, Melissa J.; Indap, Amit; Kosiol, Carolin; Lahn, Bruce T.; Lawson, Heather A.; Marklein, Alison; Nielsen, Rasmus; Vallender, Eric J.; Clark, Andrew G.; Ferguson, Betsy; Hernandez, Ryan D.; Hirani, Kashif; Kehrer-Sawatzki, Hildegard; Kolb, Jessica; Patil, Shobha; Pu, Ling Ling; Ren, Yanru; Smith, David Glenn; Wheeler, David A.; Schenck, Ian; Ball, Edward V.; Chen, Rui; Cooper, David N.; Giardine, Belinda; Hsu, Fan; Kent, W. James; Lesk, Arthur; Nelson, David L.; O'Brien, William E.; Prüfer, Kay; Stenson, Peter D.; Wallace, James C.; Ke, Hui; Liu, Xiao Ming; Wang, Peng; Xiang, Andy Peng; Yang, Fan; Barber, Gait P.; Haussler, David; Karolchik, Donna; Kern, Andy D.; Kuhn, Robert M.; Smith, Kayla E.; Zwieg, Ann S.
In: Science, Vol. 316, No. 5822, 13.04.2007, p. 222-234.Research output: Contribution to journal › Review article › peer-review
TY - JOUR
T1 - Evolutionary and biomedical insights from the rhesus macaque genome
AU - Gibbs, Richard A.
AU - Rogers, Jeffrey
AU - Katze, Michael G.
AU - Bumgarner, Roger
AU - Weinstock, George M.
AU - Mardis, Elaine R.
AU - Remington, Karin A.
AU - Strausberg, Robert L.
AU - Venter, J. Craig
AU - Wilson, Richard K.
AU - Batzer, Mark A.
AU - Bustamante, Carlos D.
AU - Eichler, Evan E.
AU - Hahn, Matthew W.
AU - Hardison, Ross C.
AU - Makova, Kateryna D.
AU - Miller, Webb
AU - Milosavljevic, Aleksandar
AU - Palermo, Robert E.
AU - Siepel, Adam
AU - Sikela, James M.
AU - Attaway, Tony
AU - Bell, Stephanie
AU - Bernard, Kelly E.
AU - Buhay, Christian J.
AU - Chandrabose, Mimi N.
AU - Dao, Marvin
AU - Davis, Clay
AU - Delehaunty, Kimberly D.
AU - Ding, Yan
AU - Dinh, Huyen H.
AU - Dugan-Rocha, Shannon
AU - Fulton, Lucinda A.
AU - Gabisi, Ramatu Ayiesha
AU - Garner, Toni T.
AU - Godfrey, Jennifer
AU - Hawes, Alicia C.
AU - Hernandez, Judith
AU - Hines, Sandra
AU - Holder, Michael
AU - Hume, Jennifer
AU - Jhangiani, Shalini N.
AU - Joshi, Vandita
AU - Khan, Ziad Mohid
AU - Kirkness, Ewen F.
AU - Cree, Andrew
AU - Fowler, R. Gerald
AU - Lee, Sandra
AU - Lewis, Lora R.
AU - Li, Zhangwan
AU - Liu, Yih Shin
AU - Moore, Stephanie M.
AU - Muzny, Donna
AU - Nazareth, Lynne V.
AU - Dinh, Ngoc Ngo
AU - Okwuonu, Geoffrey O.
AU - Pai, Grace
AU - Parker, David
AU - Paul, Heidie A.
AU - Pfannkoch, Cynthia
AU - Pohl, Craig S.
AU - Rogers, Yu Hui
AU - Ruiz, San Juana
AU - Sabo, Aniko
AU - Santibanez, Jireh
AU - Schneider, Brian W.
AU - Smith, Scott M.
AU - Sodergren, Erica
AU - Svatek, Amanda F.
AU - Utterback, Teresa R.
AU - Vattathil, Selina
AU - Warren, Wesley
AU - White, Courtney Sherell
AU - Chinwalla, Asif T.
AU - Feng, Yucheng
AU - Halpern, Aaron L.
AU - Hillier, La Deana W.
AU - Huang, Xiaoqiu
AU - Minx, Pat
AU - Nelson, Joanne O.
AU - Pepin, Kymbertie H.
AU - Qin, Xiang
AU - Sutton, Granger G.
AU - Venter, Eli
AU - Walenz, Brian P.
AU - Wallis, John W.
AU - Worley, Kim C.
AU - Yang, Shiaw Pyng
AU - Jones, Steven M.
AU - Marra, Marco A.
AU - Rocchi, Mariano
AU - Schein, Jacqueline E.
AU - Baertsch, Robert
AU - Clarke, Laura
AU - Csürös, Miklós
AU - Glasscock, Jarret
AU - Harris, R. Alan
AU - Havlak, Paul
AU - Jackson, Andrew R.
AU - Jiang, Huaiyang
AU - Liu, Yue
AU - Messina, David N.
AU - Shen, Yufeng
AU - Song, Henry Xing Zhi
AU - Wylie, Todd
AU - Zhang, Lan
AU - Birney, Ewan
AU - Han, Kyudong
AU - Konkel, Miriam K.
AU - Lee, Jungnam
AU - Smit, Arian F.A.
AU - Ullmer, Brygg
AU - Wang, Hui
AU - Xing, Jinchuan
AU - Burhans, Richard
AU - Cheng, Ze
AU - Karro, John E.
AU - Ma, Jian
AU - Raney, Brian
AU - She, Xinwei
AU - Cox, Michael J.
AU - Demuth, Jeffery P.
AU - Dumas, Laura J.
AU - Han, Sang Gook
AU - Hopkins, Janet
AU - Karimpour-Fard, Anis
AU - Kim, Young H.
AU - Pollack, Jonathan R.
AU - Vinar, Tomas
AU - Addo-Quaye, Charles
AU - Degenhardt, Jeremiah
AU - Denby, Alexandra
AU - Hubisz, Melissa J.
AU - Indap, Amit
AU - Kosiol, Carolin
AU - Lahn, Bruce T.
AU - Lawson, Heather A.
AU - Marklein, Alison
AU - Nielsen, Rasmus
AU - Vallender, Eric J.
AU - Clark, Andrew G.
AU - Ferguson, Betsy
AU - Hernandez, Ryan D.
AU - Hirani, Kashif
AU - Kehrer-Sawatzki, Hildegard
AU - Kolb, Jessica
AU - Patil, Shobha
AU - Pu, Ling Ling
AU - Ren, Yanru
AU - Smith, David Glenn
AU - Wheeler, David A.
AU - Schenck, Ian
AU - Ball, Edward V.
AU - Chen, Rui
AU - Cooper, David N.
AU - Giardine, Belinda
AU - Hsu, Fan
AU - Kent, W. James
AU - Lesk, Arthur
AU - Nelson, David L.
AU - O'Brien, William E.
AU - Prüfer, Kay
AU - Stenson, Peter D.
AU - Wallace, James C.
AU - Ke, Hui
AU - Liu, Xiao Ming
AU - Wang, Peng
AU - Xiang, Andy Peng
AU - Yang, Fan
AU - Barber, Gait P.
AU - Haussler, David
AU - Karolchik, Donna
AU - Kern, Andy D.
AU - Kuhn, Robert M.
AU - Smith, Kayla E.
AU - Zwieg, Ann S.
N1 - Copyright: Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2007/4/13
Y1 - 2007/4/13
N2 - The rhesus macaque (Macaca mulatta) is an abundant primate species that diverged from the ancestors of Homo sapiens about 25 million years ago. Because they are genetically and physiologically similar to humans, rhesus monkeys are the most widely used nonhuman primate in basic and applied biomedical research. We determined the genome sequence of an Indian-origin Macaca mulatta female and compared the data with chimpanzees and humans to reveal the structure of ancestral primate genomes and to identify evidence for positive selection and lineage-specific expansions and contractions of gene families. A comparison of sequences from individual animals was used to investigate their underlying genetic diversity. The complete description of the macaque genome blueprint enhances the utility of this animal model for biomedical research and improves our understanding of the basic biology of the species.
AB - The rhesus macaque (Macaca mulatta) is an abundant primate species that diverged from the ancestors of Homo sapiens about 25 million years ago. Because they are genetically and physiologically similar to humans, rhesus monkeys are the most widely used nonhuman primate in basic and applied biomedical research. We determined the genome sequence of an Indian-origin Macaca mulatta female and compared the data with chimpanzees and humans to reveal the structure of ancestral primate genomes and to identify evidence for positive selection and lineage-specific expansions and contractions of gene families. A comparison of sequences from individual animals was used to investigate their underlying genetic diversity. The complete description of the macaque genome blueprint enhances the utility of this animal model for biomedical research and improves our understanding of the basic biology of the species.
UR - http://www.scopus.com/inward/record.url?scp=34247352040&partnerID=8YFLogxK
U2 - 10.1126/science.1139247
DO - 10.1126/science.1139247
M3 - Review article
C2 - 17431167
AN - SCOPUS:34247352040
VL - 316
SP - 222
EP - 234
JO - Science
JF - Science
SN - 0036-8075
IS - 5822
ER -