Evolution of resistance in vitro reveals mechanisms of artemisinin activity in Toxoplasma gondii

Keyphrases

• Toxoplasma Gondii (T. gondii) 100%
• Artemisinin 100%
• Resistance Evolution 100%
• Point mutation 50%
• Mitochondria 50%
• Artemisinin Resistance 50%
• Cas9 Protein 25%
• Tumor Cells 25%
• Mitochondrial DNA 25%
• Whole Genome Sequencing 25%
• Unknown Function 25%
• IC50 Value 25%
• High Concentration 25%
• Plasmodium Falciparum 25%
• Genome Editing 25%
• Malaria 25%
• Serine Protease 25%
• Cytochrome b 25%
• Amino Acid Variation 25%
• Serine-threonine Kinase 25%
• Resistance Mechanisms 25%
• Mitochondrial Membrane Potential 25%
• Nonconservative 25%
• Single-point mutation 25%
• Competitive Advantage 25%
• Treatment Line 25%
• Tractability 25%
• DegP 25%
• Drug-resistant Parasites 25%
• Delayed Clearance 25%
• Kelch13 25%
• Cytochrome Oxidase I 25%
• Resistant Lines 25%
• Double mutation 25%

Immunology and Microbiology

• Wild Type 100%
• Toxoplasma gondii 100%
• Point Mutation 100%
• Mitochondrion 100%
• Serine 100%
• Cytochrome 100%
• Tumor Cell 50%
• EC50 50%
• Plasmodium falciparum 50%
• CRISPR/Cas9 50%
• Gene Editing 50%
• Mitochondrial Genome 50%
• Mitochondrial Membrane Potential 50%
• Amino Acid 50%
• Threonine 50%

Biochemistry, Genetics and Molecular Biology

• Wild Type 100%
• Toxoplasma gondii 100%
• Point Mutation 100%
• Mitochondrion 100%
• Genetics 50%
• CRISPR/Cas9 50%
• Amino Acids 50%
• Plasmodium falciparum 50%
• Genome Editing 50%
• Mitochondrial Genome 50%
• Cytochrome C Oxidase 50%
• EC50 50%
• Serine Protease 50%
• Mitochondrial Membrane Potential 50%
• Casein Kinase 50%
• Cytochrome B 50%