Evolution of human von Willebrand factor: CDNA sequence polymorphisms, repeated domains, and relationship to von Willebrand antigen II

Beverley B. Shelton-Inloes, George J. Broze, Joseph P. Miletich, J. Evan Sadler

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Four cDNAs extending into the 5′-noncoding region of the human von Willebrand factor cDNA have been characterized. Thirty-four residues of amino-terminal protein sequence for von Willebrand antigen II matched that predicted from the cDNA sequence, confirming that the propeptide of von Willebrand factor is von Willebrand antigen II. Among the known cDNA sequences there are four confirmed single nucleotide differences, of which two may be in linkage disequilibrium, and two would alter the protein sequence. Based on comparisons among the four repeated D domains, an evolutional model has been proposed to account for the distribution of these sequence elements in prepro-von Willebrand factor.

Original languageEnglish
Pages (from-to)657-665
Number of pages9
JournalBiochemical and Biophysical Research Communications
Volume144
Issue number2
DOIs
StatePublished - Apr 29 1987

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