Evolution of abnormal plasma glucagon responses tomixed-meal feedings in youthwith type 1 diabetes during the first 2 years after diagnosis

Jennifer Sherr, Eva Tsalikian, Larry Fox, Bruce Buckingham, Stuart Weinzimer, William V. Tamborlane, Neil H. White, Ana Maria Arbelaez, Craig Kollman, Katrina J. Ruedy, Peiyao Cheng, Roy W. Beck

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31 Scopus citations

Abstract

OBJECTIVE To examine the evolution of the dysregulated glucagon responses to mixed-meal tolerance tests (MMTTs) in youth with recent-onset type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS MMTTs were performed in 25 youth (9-18 years of age) with 1.5-12 months disease duration (year 1); 22 subjects were restudied 1 year later (year 2). Twenty nondiabetic (ND) control children were also studied. RESULTS In T1D children,MMTT-stimulated increases in glucagonwere significantly greater than that in ND children (median increments: year 1, 21 pg/mL [16-30]; year 2, 25 pg/mL [16-30]; ND, 9 pg/mL [5-16]; P = 0.001 and P > 0.001, respectively). CONCLUSIONS In comparison with ND control children, exaggerated plasma glucagon responses to mixed-meal feedings are observed in youth with T1D within the first 2 years of diagnosis. Further studies to determine whether suppression of these abnormal responses may help to improve glycemic control are warranted.

Original languageEnglish
Pages (from-to)1741-1744
Number of pages4
JournalDiabetes care
Volume37
Issue number6
DOIs
StatePublished - Jun 2014

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