Evolution and implementation of radiographic response criteria in neuro-oncology

Divya Ramakrishnan, Marc Von Reppert, Mark Krycia, Matthew Sala, Sabine Mueller, Sanjay Aneja, Ali Nabavizadeh, Norbert Galldiks, Philipp Lohmann, Cyrus Raji, Ichiro Ikuta, Fatima Memon, Brent D. Weinberg, Mariam S. Aboian

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Radiographic response assessment in neuro-oncology is critical in clinical practice and trials. Conventional criteria, such as the MacDonald and response assessment in neuro-oncology (RANO) criteria, rely on bidimensional (2D) measurements of a single tumor cross-section. Although RANO criteria are established for response assessment in clinical trials, there is a critical need to address the complexity of brain tumor treatment response with multiple new approaches being proposed. These include volumetric analysis of tumor compartments, structured MRI reporting systems like the Brain Tumor Reporting and Data System, and standardized approaches to advanced imaging techniques to distinguish tumor response from treatment effects. In this review, we discuss the strengths and limitations of different neuro-oncology response criteria and summarize current research findings on the role of novel response methods in neuro-oncology clinical trials and practice.

Original languageEnglish
Article numbervdad118
JournalNeuro-Oncology Advances
Issue number1
StatePublished - Jan 1 2023


  • RANO
  • Response Assessment
  • Volumetrics


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