Evidence that thymocytes require at least two distinct signals to proliferate

D. I. Beller; E. R. Unanue

Evidence that thymocytes require at least two distinct signals to proliferate

D. I. Beller, E. R. Unanue

Research output: Contribution to journal › Article › peer-review

Abstract

Optimal receptivity of thymocytes to the mitogenic stimulus in macrophage culture fluid (MCF) is limited to the time in culture when these cells are spontaneously proliferating. By providing a brief, nonmitogenic lectin pulse, nonproliferating cells can be 'activated' and their ability to respond to MCF totally restored. This procedure provides a model system for evaluating thymocyte proliferation and, in particular, the mechanism of action of MCF.

Original language	English
Pages (from-to)	2890-2893
Number of pages	4
Journal	Journal of Immunology
Volume	123
Issue number	6
State	Published - Dec 1 1979

Cite this

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title = "Evidence that thymocytes require at least two distinct signals to proliferate",

abstract = "Optimal receptivity of thymocytes to the mitogenic stimulus in macrophage culture fluid (MCF) is limited to the time in culture when these cells are spontaneously proliferating. By providing a brief, nonmitogenic lectin pulse, nonproliferating cells can be 'activated' and their ability to respond to MCF totally restored. This procedure provides a model system for evaluating thymocyte proliferation and, in particular, the mechanism of action of MCF.",

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AU - Unanue, E. R.

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N2 - Optimal receptivity of thymocytes to the mitogenic stimulus in macrophage culture fluid (MCF) is limited to the time in culture when these cells are spontaneously proliferating. By providing a brief, nonmitogenic lectin pulse, nonproliferating cells can be 'activated' and their ability to respond to MCF totally restored. This procedure provides a model system for evaluating thymocyte proliferation and, in particular, the mechanism of action of MCF.

AB - Optimal receptivity of thymocytes to the mitogenic stimulus in macrophage culture fluid (MCF) is limited to the time in culture when these cells are spontaneously proliferating. By providing a brief, nonmitogenic lectin pulse, nonproliferating cells can be 'activated' and their ability to respond to MCF totally restored. This procedure provides a model system for evaluating thymocyte proliferation and, in particular, the mechanism of action of MCF.

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EP - 2893

JO - Journal of Immunology

JF - Journal of Immunology

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Evidence that thymocytes require at least two distinct signals to proliferate

Abstract

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