TY - JOUR
T1 - Evidence that the (6-4) photolyase mechanism can proceed through an oxetane intermediate
AU - Asgatay, Saâdia
AU - Petermann, Christian
AU - Harakat, Dominique
AU - Guillaume, Dominique
AU - Taylor, John Stephen
AU - Clivio, Pascale
PY - 2008/9/24
Y1 - 2008/9/24
N2 - Using the analogue of TpT methylated at the 3′-end N3 position (Tpm3T), we demonstrate that when the oxetane/(6-4) pathway is precluded, water addition occurs at the 3′-end C6 position of the oxetane intermediate to provide its opening. Photoreversal of this (6-4) photoproduct C6 hydrate brings the first experimental evidence that the (6-4) photolyase repair can proceed through an oxetane intermediate.
AB - Using the analogue of TpT methylated at the 3′-end N3 position (Tpm3T), we demonstrate that when the oxetane/(6-4) pathway is precluded, water addition occurs at the 3′-end C6 position of the oxetane intermediate to provide its opening. Photoreversal of this (6-4) photoproduct C6 hydrate brings the first experimental evidence that the (6-4) photolyase repair can proceed through an oxetane intermediate.
UR - http://www.scopus.com/inward/record.url?scp=52449090241&partnerID=8YFLogxK
U2 - 10.1021/ja805214s
DO - 10.1021/ja805214s
M3 - Article
C2 - 18763765
AN - SCOPUS:52449090241
SN - 0002-7863
VL - 130
SP - 12618
EP - 12619
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
IS - 38
ER -