Evidence for two types of GABA-containing interneurons in the A-laminae of the cat lateral geniculate nucleus: a double-label HRP and GABA-immunocytochemical study

V. M. Montera, J. Zempel

Research output: Contribution to journalArticle

90 Scopus citations

Abstract

Neurons containing GABA immunoreactivity were analyzed in the A-laminae of normal cat LGN and of LGN retrogradely labeled with HRP from the visual cortex. In contrast to retrograde labeling of relay cells, GABA+ cells were devoid of HRP label, providing additional evidence for the interneuronal nature of GABAergic cells in the cat LGN. Cell body area measurements showed that the population of GABA+ cells is composed of a large proportion of small (β) cells and a smaller proportion of medium size (a) cells. The proportion of α GABA+ cells increases from medial to lateral parts of the A-laminae, resembling a similar medio-lateral increase of physiologically defined Y cells and of morphologically defined type 1 cells in these laminae. This suggests that the α and β GABAergic cells are related to the Y and X geniculo-cortical relay cells, respectively.

Original languageEnglish
Pages (from-to)603-609
Number of pages7
JournalExperimental Brain Research
Volume60
Issue number3
DOIs
StatePublished - Nov 1 1985

Keywords

  • GABA
  • Immunocytochemistry
  • Inhibition
  • Interneurons
  • Lateral geniculate nucleus

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