Evidence for transgenerational metabolic programming in Drosophila

Jessica L. Buescher, Laura P. Musselman, Christina A. Wilson, Tieming Lang, Madeline Keleher, Thomas J. Baranski, Jennifer G. Duncan

Research output: Contribution to journalArticlepeer-review

73 Scopus citations

Abstract

Worldwide epidemiologic studies have repeatedly demonstrated an association between prenatal nutritional environment, birth weight and susceptibility to adult diseases including obesity, cardiovascular disease and type 2 diabetes. Despite advances in mammalian model systems, the molecular mechanisms underlying this phenomenon are unclear, but might involve programming mechanisms such as epigenetics. Here we describe a new system for evaluating metabolic programming mechanisms using a simple, genetically tractable Drosophila model. We examined the effect of maternal caloric excess on offspring and found that a high-sugar maternal diet alters body composition of larval offspring for at least two generations, augments an obese-like phenotype under suboptimal (high-calorie) feeding conditions in adult offspring, and modifies expression of metabolic genes. Our data indicate that nutritional programming mechanisms could be highly conserved and support the use of Drosophila as a model for evaluating the underlying genetic and epigenetic contributions to this phenomenon.

Original languageEnglish
Pages (from-to)1123-1132
Number of pages10
JournalDMM Disease Models and Mechanisms
Volume6
Issue number5
DOIs
StatePublished - Sep 2013

Fingerprint

Dive into the research topics of 'Evidence for transgenerational metabolic programming in Drosophila'. Together they form a unique fingerprint.

Cite this