TY - JOUR
T1 - Evidence for the hemangioblast
AU - Park, Changwon
AU - Ma, Yunglin D.
AU - Choi, Kyunghee
N1 - Funding Information:
We thank the lab members for their contribution to ongoing projects. We also thank Jesse Lugus for critically reading the manuscript. We would like to thank many investigators for providing valuable reagents and apologize to the many authors that we could not cite due to space constraints. This work was supported by grants from the National Institutes of Health, NHLBI, R01s HL63736 and HL55337 (to K.C.).
PY - 2005/9
Y1 - 2005/9
N2 - In recent years, numerous cellular and genetic studies have led to a better understanding of the developmental relationship between hematopoietic and endothelial cell lineages. Specifically, tracing cells expressing various genes such as Brachyury, Flk-1, or Scl has delineated the cellular sequence leading to hematopoietic and endothelial cell development from mesoderm. Moreover, in vitro as well as in vivo studies of invertebrate and vertebrate systems have established that hematopoietic and endothelial cells develop from a common progenitor, the hemangioblast. Finally, the presence of the hemangioblast has been confirmed in postnatal mice and humans. Further characterization of the hemangioblast, both embryo and postnatal, will be critical for a better understanding of the molecular events involved in hematopoietic and endothelial cell differentiation as well as for utilizing this cell population for clinical applications.
AB - In recent years, numerous cellular and genetic studies have led to a better understanding of the developmental relationship between hematopoietic and endothelial cell lineages. Specifically, tracing cells expressing various genes such as Brachyury, Flk-1, or Scl has delineated the cellular sequence leading to hematopoietic and endothelial cell development from mesoderm. Moreover, in vitro as well as in vivo studies of invertebrate and vertebrate systems have established that hematopoietic and endothelial cells develop from a common progenitor, the hemangioblast. Finally, the presence of the hemangioblast has been confirmed in postnatal mice and humans. Further characterization of the hemangioblast, both embryo and postnatal, will be critical for a better understanding of the molecular events involved in hematopoietic and endothelial cell differentiation as well as for utilizing this cell population for clinical applications.
UR - http://www.scopus.com/inward/record.url?scp=24044441296&partnerID=8YFLogxK
U2 - 10.1016/j.exphem.2005.06.003
DO - 10.1016/j.exphem.2005.06.003
M3 - Article
C2 - 16140143
AN - SCOPUS:24044441296
SN - 0301-472X
VL - 33
SP - 965
EP - 970
JO - Experimental Hematology
JF - Experimental Hematology
IS - 9 SPEC. ISS.
ER -