Evidence for specificity of transmission of alcohol and nicotine dependence in an offspring of twins design

Heather E. Volk; Jeffrey F. Scherrer; Kathleen K. Bucholz; Alexandre Todorov; Andrew C. Heath; Theodore Jacob; William R. True

doi:10.1016/j.drugalcdep.2006.08.023

Evidence for specificity of transmission of alcohol and nicotine dependence in an offspring of twins design

Heather E. Volk, Jeffrey F. Scherrer, Kathleen K. Bucholz, Alexandre Todorov, Andrew C. Heath, Theodore Jacob, William R. True

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Alcohol dependence (AD) and nicotine dependence (ND) have been shown to co-occur. Results from twin studies implicate the role of genetics in the etiology of both ND and AD with substantial, yet incomplete, overlap. To test for specificity of transmission of AD and ND in an offspring of twins sample we analyzed data from a study of adolescent and adult offspring of twin fathers ascertained from the Vietnam Era Twin Registry. This sample consists of 1213 twin fathers, 862 biologic or rearing mothers, and 1270 offspring. Offspring were allocated to one of four risk groups for AD based on twin fathers' zygosity and father's and cotwins AD history. Offspring DSM-IV AD and ND were measured by structured diagnostic interview. Paternal AD and ND were significantly associated with offspring AD and ND, respectively. Bivariate probit regression results suggest specificity for transmission of AD and ND. This remained constant after controlling for offspring demographics and psychopathology and maternal AD and ND. Despite the substantial genetic overlap between the two disorders, there is evidence for genetic effects specific for AD and ND.

Original language	English
Pages (from-to)	225-232
Number of pages	8
Journal	Drug and Alcohol Dependence
Volume	87
Issue number	2-3
DOIs	https://doi.org/10.1016/j.drugalcdep.2006.08.023
State	Published - Mar 16 2007

Keywords

Alcohol
Genetic
Nicotine
Specificity
Twin-family

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10.1016/j.drugalcdep.2006.08.023

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title = "Evidence for specificity of transmission of alcohol and nicotine dependence in an offspring of twins design",

abstract = "Alcohol dependence (AD) and nicotine dependence (ND) have been shown to co-occur. Results from twin studies implicate the role of genetics in the etiology of both ND and AD with substantial, yet incomplete, overlap. To test for specificity of transmission of AD and ND in an offspring of twins sample we analyzed data from a study of adolescent and adult offspring of twin fathers ascertained from the Vietnam Era Twin Registry. This sample consists of 1213 twin fathers, 862 biologic or rearing mothers, and 1270 offspring. Offspring were allocated to one of four risk groups for AD based on twin fathers' zygosity and father's and cotwins AD history. Offspring DSM-IV AD and ND were measured by structured diagnostic interview. Paternal AD and ND were significantly associated with offspring AD and ND, respectively. Bivariate probit regression results suggest specificity for transmission of AD and ND. This remained constant after controlling for offspring demographics and psychopathology and maternal AD and ND. Despite the substantial genetic overlap between the two disorders, there is evidence for genetic effects specific for AD and ND.",

keywords = "Alcohol, Genetic, Nicotine, Specificity, Twin-family",

author = "Volk, {Heather E.} and Scherrer, {Jeffrey F.} and Bucholz, {Kathleen K.} and Alexandre Todorov and Heath, {Andrew C.} and Theodore Jacob and True, {William R.}",

note = "Funding Information: This work has been supported by AA11822, AA11667, AA11998, AA07728, DA14363, MH074272. The United States Department of Veterans Affairs has provided financial support for the development and maintenance of the Vietnam Era Twin (VET) Registry. Numerous organizations have provided invaluable assistance in the conduct of this study, including: Department of Defense; National Personnel Records Center, National Archives and Records Administration; the Internal Revenue Service; National Opinion Research Center; National Research Council, National Academy of Sciences; the Institute for Survey Research, Temple University. Most importantly, the authors gratefully acknowledge the continued cooperation and participation of the members of the VET Registry. Without their contribution this research would not have been possible. ",

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doi = "10.1016/j.drugalcdep.2006.08.023",

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AU - Volk, Heather E.

AU - Scherrer, Jeffrey F.

AU - Bucholz, Kathleen K.

AU - Todorov, Alexandre

AU - Heath, Andrew C.

AU - Jacob, Theodore

AU - True, William R.

N1 - Funding Information: This work has been supported by AA11822, AA11667, AA11998, AA07728, DA14363, MH074272. The United States Department of Veterans Affairs has provided financial support for the development and maintenance of the Vietnam Era Twin (VET) Registry. Numerous organizations have provided invaluable assistance in the conduct of this study, including: Department of Defense; National Personnel Records Center, National Archives and Records Administration; the Internal Revenue Service; National Opinion Research Center; National Research Council, National Academy of Sciences; the Institute for Survey Research, Temple University. Most importantly, the authors gratefully acknowledge the continued cooperation and participation of the members of the VET Registry. Without their contribution this research would not have been possible.

PY - 2007/3/16

Y1 - 2007/3/16

N2 - Alcohol dependence (AD) and nicotine dependence (ND) have been shown to co-occur. Results from twin studies implicate the role of genetics in the etiology of both ND and AD with substantial, yet incomplete, overlap. To test for specificity of transmission of AD and ND in an offspring of twins sample we analyzed data from a study of adolescent and adult offspring of twin fathers ascertained from the Vietnam Era Twin Registry. This sample consists of 1213 twin fathers, 862 biologic or rearing mothers, and 1270 offspring. Offspring were allocated to one of four risk groups for AD based on twin fathers' zygosity and father's and cotwins AD history. Offspring DSM-IV AD and ND were measured by structured diagnostic interview. Paternal AD and ND were significantly associated with offspring AD and ND, respectively. Bivariate probit regression results suggest specificity for transmission of AD and ND. This remained constant after controlling for offspring demographics and psychopathology and maternal AD and ND. Despite the substantial genetic overlap between the two disorders, there is evidence for genetic effects specific for AD and ND.

AB - Alcohol dependence (AD) and nicotine dependence (ND) have been shown to co-occur. Results from twin studies implicate the role of genetics in the etiology of both ND and AD with substantial, yet incomplete, overlap. To test for specificity of transmission of AD and ND in an offspring of twins sample we analyzed data from a study of adolescent and adult offspring of twin fathers ascertained from the Vietnam Era Twin Registry. This sample consists of 1213 twin fathers, 862 biologic or rearing mothers, and 1270 offspring. Offspring were allocated to one of four risk groups for AD based on twin fathers' zygosity and father's and cotwins AD history. Offspring DSM-IV AD and ND were measured by structured diagnostic interview. Paternal AD and ND were significantly associated with offspring AD and ND, respectively. Bivariate probit regression results suggest specificity for transmission of AD and ND. This remained constant after controlling for offspring demographics and psychopathology and maternal AD and ND. Despite the substantial genetic overlap between the two disorders, there is evidence for genetic effects specific for AD and ND.

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Evidence for specificity of transmission of alcohol and nicotine dependence in an offspring of twins design

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