TY - JOUR
T1 - Evidence for internal homology in bovine preproparathyroid hormone
AU - Cohn, D. V.
AU - Smardo, F. L.
AU - Morrissey, J. J.
PY - 1979
Y1 - 1979
N2 - By means of a statistical method for detecting distant evolutionary relationships between proteins, we found a high probability that internal homologies exist in preproparathyroid hormone, the biological precursor of proparathyroid hormone and parathyroid hormone. The regions so defined were -27 to +22 of preproparathyroid hormone vs. +26 to +74 parathyroid hormone and -23 to +29 of preproparathyroid hormone vs. +30 to +81 of parathyroid hormone. Examination of these regions for possible similarities of internal secondary structure (β turns, α helix, and β sheet) by a second type of predictive formulation indicated that most of the regions calculated to be related on an evolutionary basis were likewise homologous in terms of structure. These results and other considerations suggest that a primitive form of parathyroid hormone, possibly of pituitary origin, existed (or still exists). Parathyroid hormone of higher species likely was formed by gene doubling and fusion of the primitive gene.
AB - By means of a statistical method for detecting distant evolutionary relationships between proteins, we found a high probability that internal homologies exist in preproparathyroid hormone, the biological precursor of proparathyroid hormone and parathyroid hormone. The regions so defined were -27 to +22 of preproparathyroid hormone vs. +26 to +74 parathyroid hormone and -23 to +29 of preproparathyroid hormone vs. +30 to +81 of parathyroid hormone. Examination of these regions for possible similarities of internal secondary structure (β turns, α helix, and β sheet) by a second type of predictive formulation indicated that most of the regions calculated to be related on an evolutionary basis were likewise homologous in terms of structure. These results and other considerations suggest that a primitive form of parathyroid hormone, possibly of pituitary origin, existed (or still exists). Parathyroid hormone of higher species likely was formed by gene doubling and fusion of the primitive gene.
UR - http://www.scopus.com/inward/record.url?scp=0018350437&partnerID=8YFLogxK
U2 - 10.1073/pnas.76.3.1469
DO - 10.1073/pnas.76.3.1469
M3 - Article
C2 - 286332
AN - SCOPUS:0018350437
SN - 0027-8424
VL - 76
SP - 1469
EP - 1471
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 3
ER -