Evidence for independent peripheral and central age-related hearing impairment

Jianxin Bao, Yan Yu, Hui Li, John Hawks, Grace Szatkowski, Bethany Dade, Hao Wang, Peng Liu, Thomas Brutnell, Brent Spehar, Nancy Tye-Murray

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Deleterious age-related changes in the central auditory nervous system have been referred to as central age-related hearing impairment (ARHI) or central presbycusis. Central ARHI is often assumed to be the consequence of peripheral ARHI. However, it is possible that certain aspects of central ARHI are independent from peripheral ARHI. A confirmation of this possibility could lead to significant improvements in current rehabilitation practices. The major difficulty in addressing this issue arises from confounding factors, such as other age-related changes in both the cochlea and central non-auditory brain structures. Because gap detection is a common measure of central auditory temporal processing, and gap detection thresholds are less influenced by changes in other brain functions such as learning and memory, we investigated the potential relationship between age-related peripheral hearing loss (i.e., audiograms) and age-related changes in gap detection. Consistent with previous studies, a significant difference was found for gap detection thresholds between young and older adults. However, among older adults, no significant associations were observed between gap detection ability and several other independent variables including the pure tone audiogram average, the Wechsler Adult Intelligence Scale-Vocabulary score, gender, and age. Statistical analyses showed little or no contributions from these independent variables to gap detection thresholds. Thus, our data indicate that age-related decline in central temporal processing is largely independent of peripheral ARHI.

Original languageEnglish
Pages (from-to)1800-1814
Number of pages15
JournalJournal of Neuroscience Research
Volume98
Issue number9
DOIs
StatePublished - Sep 1 2020

Keywords

  • age-related hearing impairment
  • central presbycusis
  • peripheral hearing loss
  • temporal processing

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