Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence

Arpana Agrawal; Leah Wetherill; Danielle M. Dick; Xiaoling Xuei; Anthony Hinrichs; Victor Hesselbrock; John Kramer; John I. Nurnberger; Marc Schuckit; Laura J. Bierut; Howard J. Edenberg; Tatiana Foroud

doi:10.1002/ajmg.b.30881

Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence

Arpana Agrawal
, Leah Wetherill
, Danielle M. Dick
, Xiaoling Xuei
, Anthony Hinrichs
, Victor Hesselbrock
, John Kramer
, John I. Nurnberger
, Marc Schuckit
, Laura J. Bierut
, Howard J. Edenberg
, Tatiana Foroud

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

Genomic studies of cannabis use disorders have been limited. The cannabinoid receptor 1 gene (CNR1) on chromosome 6q14-15 is an excellent candidate gene for cannabis dependence due to the important role of the G-protein coupled receptor encoded by this gene in the rewarding effects of Δ9-tetrahydrocannabinol. Previous studies have found equivocal evidence for an association between SNPs in CNR1 and a general vulnerability to substance use disorders. We investigate the association between 9 SNPs spanning CNR1 and cannabis dependence in 1,923 individuals. Two SNPs that were previously associated with cannabis dependence in other studies were also significant with this phenotype in our analyses [rs806368 (P=0.05) and rs806380 (P=0.009)]. Haplotype analyses revealed the association to be largely driven by the SNP rs806380. These results suggest a role for the cannabinoid receptor 1 gene in cannabis dependence.

Original language	English
Pages (from-to)	736-740
Number of pages	5
Journal	American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume	150
Issue number	5
DOIs	https://doi.org/10.1002/ajmg.b.30881
State	Published - Jul 5 2009

Keywords

Association
CNR1
COGA
Cannabis dependence
Pedigree disequilibrium test

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Agrawal, A., Wetherill, L., Dick, D. M., Xuei, X., Hinrichs, A., Hesselbrock, V., Kramer, J., Nurnberger, J. I., Schuckit, M., Bierut, L. J., Edenberg, H. J., & Foroud, T. (2009). Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 150(5), 736-740. https://doi.org/10.1002/ajmg.b.30881

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title = "Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence",

abstract = "Genomic studies of cannabis use disorders have been limited. The cannabinoid receptor 1 gene (CNR1) on chromosome 6q14-15 is an excellent candidate gene for cannabis dependence due to the important role of the G-protein coupled receptor encoded by this gene in the rewarding effects of Δ9-tetrahydrocannabinol. Previous studies have found equivocal evidence for an association between SNPs in CNR1 and a general vulnerability to substance use disorders. We investigate the association between 9 SNPs spanning CNR1 and cannabis dependence in 1,923 individuals. Two SNPs that were previously associated with cannabis dependence in other studies were also significant with this phenotype in our analyses [rs806368 (P=0.05) and rs806380 (P=0.009)]. Haplotype analyses revealed the association to be largely driven by the SNP rs806380. These results suggest a role for the cannabinoid receptor 1 gene in cannabis dependence.",

keywords = "Association, CNR1, COGA, Cannabis dependence, Pedigree disequilibrium test",

author = "Arpana Agrawal and Leah Wetherill and Dick, \{Danielle M.\} and Xiaoling Xuei and Anthony Hinrichs and Victor Hesselbrock and John Kramer and Nurnberger, \{John I.\} and Marc Schuckit and Bierut, \{Laura J.\} and Edenberg, \{Howard J.\} and Tatiana Foroud",

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Agrawal, A, Wetherill, L, Dick, DM, Xuei, X, Hinrichs, A, Hesselbrock, V, Kramer, J, Nurnberger, JI, Schuckit, M, Bierut, LJ, Edenberg, HJ & Foroud, T 2009, 'Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence', American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, vol. 150, no. 5, pp. 736-740. https://doi.org/10.1002/ajmg.b.30881

TY - JOUR

T1 - Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence

AU - Agrawal, Arpana

AU - Wetherill, Leah

AU - Dick, Danielle M.

AU - Xuei, Xiaoling

AU - Hinrichs, Anthony

AU - Hesselbrock, Victor

AU - Kramer, John

AU - Nurnberger, John I.

AU - Schuckit, Marc

AU - Bierut, Laura J.

AU - Edenberg, Howard J.

AU - Foroud, Tatiana

PY - 2009/7/5

Y1 - 2009/7/5

N2 - Genomic studies of cannabis use disorders have been limited. The cannabinoid receptor 1 gene (CNR1) on chromosome 6q14-15 is an excellent candidate gene for cannabis dependence due to the important role of the G-protein coupled receptor encoded by this gene in the rewarding effects of Δ9-tetrahydrocannabinol. Previous studies have found equivocal evidence for an association between SNPs in CNR1 and a general vulnerability to substance use disorders. We investigate the association between 9 SNPs spanning CNR1 and cannabis dependence in 1,923 individuals. Two SNPs that were previously associated with cannabis dependence in other studies were also significant with this phenotype in our analyses [rs806368 (P=0.05) and rs806380 (P=0.009)]. Haplotype analyses revealed the association to be largely driven by the SNP rs806380. These results suggest a role for the cannabinoid receptor 1 gene in cannabis dependence.

AB - Genomic studies of cannabis use disorders have been limited. The cannabinoid receptor 1 gene (CNR1) on chromosome 6q14-15 is an excellent candidate gene for cannabis dependence due to the important role of the G-protein coupled receptor encoded by this gene in the rewarding effects of Δ9-tetrahydrocannabinol. Previous studies have found equivocal evidence for an association between SNPs in CNR1 and a general vulnerability to substance use disorders. We investigate the association between 9 SNPs spanning CNR1 and cannabis dependence in 1,923 individuals. Two SNPs that were previously associated with cannabis dependence in other studies were also significant with this phenotype in our analyses [rs806368 (P=0.05) and rs806380 (P=0.009)]. Haplotype analyses revealed the association to be largely driven by the SNP rs806380. These results suggest a role for the cannabinoid receptor 1 gene in cannabis dependence.

KW - Association

KW - CNR1

KW - COGA

KW - Cannabis dependence

KW - Pedigree disequilibrium test

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DO - 10.1002/ajmg.b.30881

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AN - SCOPUS:67649445894

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JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

IS - 5

ER -

Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence

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Keywords

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