Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence

Arpana Agrawal; Leah Wetherill; Danielle M. Dick; Xiaoling Xuei; Anthony Hinrichs; Victor Hesselbrock; John Kramer; John I. Nurnberger; Marc Schuckit; Laura J. Bierut; Howard J. Edenberg; Tatiana Foroud

doi:10.1002/ajmg.b.30881

Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence

Arpana Agrawal, Leah Wetherill, Danielle M. Dick, Xiaoling Xuei, Anthony Hinrichs, Victor Hesselbrock, John Kramer, John I. Nurnberger, Marc Schuckit, Laura J. Bierut, Howard J. Edenberg, Tatiana Foroud

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

Genomic studies of cannabis use disorders have been limited. The cannabinoid receptor 1 gene (CNR1) on chromosome 6q14-15 is an excellent candidate gene for cannabis dependence due to the important role of the G-protein coupled receptor encoded by this gene in the rewarding effects of Δ9-tetrahydrocannabinol. Previous studies have found equivocal evidence for an association between SNPs in CNR1 and a general vulnerability to substance use disorders. We investigate the association between 9 SNPs spanning CNR1 and cannabis dependence in 1,923 individuals. Two SNPs that were previously associated with cannabis dependence in other studies were also significant with this phenotype in our analyses [rs806368 (P=0.05) and rs806380 (P=0.009)]. Haplotype analyses revealed the association to be largely driven by the SNP rs806380. These results suggest a role for the cannabinoid receptor 1 gene in cannabis dependence.

Original language	English
Pages (from-to)	736-740
Number of pages	5
Journal	American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume	150
Issue number	5
DOIs	https://doi.org/10.1002/ajmg.b.30881
State	Published - Jul 5 2009

Keywords

Association
CNR1
COGA
Cannabis dependence
Pedigree disequilibrium test

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Agrawal, A., Wetherill, L., Dick, D. M., Xuei, X., Hinrichs, A., Hesselbrock, V., Kramer, J., Nurnberger, J. I., Schuckit, M., Bierut, L. J., Edenberg, H. J., & Foroud, T. (2009). Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 150(5), 736-740. https://doi.org/10.1002/ajmg.b.30881

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title = "Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence",

abstract = "Genomic studies of cannabis use disorders have been limited. The cannabinoid receptor 1 gene (CNR1) on chromosome 6q14-15 is an excellent candidate gene for cannabis dependence due to the important role of the G-protein coupled receptor encoded by this gene in the rewarding effects of Δ9-tetrahydrocannabinol. Previous studies have found equivocal evidence for an association between SNPs in CNR1 and a general vulnerability to substance use disorders. We investigate the association between 9 SNPs spanning CNR1 and cannabis dependence in 1,923 individuals. Two SNPs that were previously associated with cannabis dependence in other studies were also significant with this phenotype in our analyses [rs806368 (P=0.05) and rs806380 (P=0.009)]. Haplotype analyses revealed the association to be largely driven by the SNP rs806380. These results suggest a role for the cannabinoid receptor 1 gene in cannabis dependence.",

keywords = "Association, CNR1, COGA, Cannabis dependence, Pedigree disequilibrium test",

author = "Arpana Agrawal and Leah Wetherill and Dick, {Danielle M.} and Xiaoling Xuei and Anthony Hinrichs and Victor Hesselbrock and John Kramer and Nurnberger, {John I.} and Marc Schuckit and Bierut, {Laura J.} and Edenberg, {Howard J.} and Tatiana Foroud",

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Agrawal, A, Wetherill, L, Dick, DM, Xuei, X, Hinrichs, A, Hesselbrock, V, Kramer, J, Nurnberger, JI, Schuckit, M, Bierut, LJ, Edenberg, HJ & Foroud, T 2009, 'Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence', American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, vol. 150, no. 5, pp. 736-740. https://doi.org/10.1002/ajmg.b.30881

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AU - Agrawal, Arpana

AU - Wetherill, Leah

AU - Dick, Danielle M.

AU - Xuei, Xiaoling

AU - Hinrichs, Anthony

AU - Hesselbrock, Victor

AU - Kramer, John

AU - Nurnberger, John I.

AU - Schuckit, Marc

AU - Bierut, Laura J.

AU - Edenberg, Howard J.

AU - Foroud, Tatiana

PY - 2009/7/5

Y1 - 2009/7/5

N2 - Genomic studies of cannabis use disorders have been limited. The cannabinoid receptor 1 gene (CNR1) on chromosome 6q14-15 is an excellent candidate gene for cannabis dependence due to the important role of the G-protein coupled receptor encoded by this gene in the rewarding effects of Δ9-tetrahydrocannabinol. Previous studies have found equivocal evidence for an association between SNPs in CNR1 and a general vulnerability to substance use disorders. We investigate the association between 9 SNPs spanning CNR1 and cannabis dependence in 1,923 individuals. Two SNPs that were previously associated with cannabis dependence in other studies were also significant with this phenotype in our analyses [rs806368 (P=0.05) and rs806380 (P=0.009)]. Haplotype analyses revealed the association to be largely driven by the SNP rs806380. These results suggest a role for the cannabinoid receptor 1 gene in cannabis dependence.

AB - Genomic studies of cannabis use disorders have been limited. The cannabinoid receptor 1 gene (CNR1) on chromosome 6q14-15 is an excellent candidate gene for cannabis dependence due to the important role of the G-protein coupled receptor encoded by this gene in the rewarding effects of Δ9-tetrahydrocannabinol. Previous studies have found equivocal evidence for an association between SNPs in CNR1 and a general vulnerability to substance use disorders. We investigate the association between 9 SNPs spanning CNR1 and cannabis dependence in 1,923 individuals. Two SNPs that were previously associated with cannabis dependence in other studies were also significant with this phenotype in our analyses [rs806368 (P=0.05) and rs806380 (P=0.009)]. Haplotype analyses revealed the association to be largely driven by the SNP rs806380. These results suggest a role for the cannabinoid receptor 1 gene in cannabis dependence.

KW - Association

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KW - COGA

KW - Cannabis dependence

KW - Pedigree disequilibrium test

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Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence

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Keywords

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