Evidence-based feeding strategies before and after the development of necrotizing enterocolitis

Misty Good; Chhinder P. Sodhi; David J. Hackam

doi:10.1586/1744666X.2014.913481

Evidence-based feeding strategies before and after the development of necrotizing enterocolitis

Misty Good
, Chhinder P. Sodhi
, David J. Hackam

Research output: Contribution to journal › Review article › peer-review

66 Scopus citations

Abstract

Necrotizing enterocolitis (NEC) is a devastating disease of premature infants and is associated with significant morbidity and mortality. While the pathogenesis of NEC remains incompletely understood, it is well established that the risk of disease is increased by the administration of infant formula and decreased by the administration of breast milk. This review will focus on the mechanisms by which breast milk may serve to protect against NEC, and will review the evidence regarding various feeding strategies that may be utilized before and after an episode of NEC.

Original language	English
Pages (from-to)	875-884
Number of pages	10
Journal	Expert Review of Clinical Immunology
Volume	10
Issue number	7
DOIs	https://doi.org/10.1586/1744666X.2014.913481
State	Published - Jul 2014

Keywords

amniotic fluid
breast milk
growth factors
innate immunity
necrotizing enterocolitis
prematurity
toll-like receptor 4

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10.1586/1744666X.2014.913481

Cite this

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title = "Evidence-based feeding strategies before and after the development of necrotizing enterocolitis",

abstract = "Necrotizing enterocolitis (NEC) is a devastating disease of premature infants and is associated with significant morbidity and mortality. While the pathogenesis of NEC remains incompletely understood, it is well established that the risk of disease is increased by the administration of infant formula and decreased by the administration of breast milk. This review will focus on the mechanisms by which breast milk may serve to protect against NEC, and will review the evidence regarding various feeding strategies that may be utilized before and after an episode of NEC.",

keywords = "amniotic fluid, breast milk, growth factors, innate immunity, necrotizing enterocolitis, prematurity, toll-like receptor 4",

author = "Misty Good and Sodhi, \{Chhinder P.\} and Hackam, \{David J.\}",

note = "Funding Information: CP Sodhi and DJ Hackam are supported by R01GM078238 and R01DK083752 from the National Institutes of Health. DJ Hackam is also supported by a research grant from Abbott Nutrition. MG is supported by 5K12HD052892-05 from the National Institutes of Health, The Children{\textquoteright}s Hospital of Pittsburgh of the UPMC Health System and The Gerber Foundation. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.",

year = "2014",

month = jul,

doi = "10.1586/1744666X.2014.913481",

language = "English",

volume = "10",

pages = "875--884",

journal = "Expert Review of Clinical Immunology",

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AU - Good, Misty

AU - Sodhi, Chhinder P.

AU - Hackam, David J.

N1 - Funding Information: CP Sodhi and DJ Hackam are supported by R01GM078238 and R01DK083752 from the National Institutes of Health. DJ Hackam is also supported by a research grant from Abbott Nutrition. MG is supported by 5K12HD052892-05 from the National Institutes of Health, The Children’s Hospital of Pittsburgh of the UPMC Health System and The Gerber Foundation. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

PY - 2014/7

Y1 - 2014/7

N2 - Necrotizing enterocolitis (NEC) is a devastating disease of premature infants and is associated with significant morbidity and mortality. While the pathogenesis of NEC remains incompletely understood, it is well established that the risk of disease is increased by the administration of infant formula and decreased by the administration of breast milk. This review will focus on the mechanisms by which breast milk may serve to protect against NEC, and will review the evidence regarding various feeding strategies that may be utilized before and after an episode of NEC.

AB - Necrotizing enterocolitis (NEC) is a devastating disease of premature infants and is associated with significant morbidity and mortality. While the pathogenesis of NEC remains incompletely understood, it is well established that the risk of disease is increased by the administration of infant formula and decreased by the administration of breast milk. This review will focus on the mechanisms by which breast milk may serve to protect against NEC, and will review the evidence regarding various feeding strategies that may be utilized before and after an episode of NEC.

KW - amniotic fluid

KW - breast milk

KW - growth factors

KW - innate immunity

KW - necrotizing enterocolitis

KW - prematurity

KW - toll-like receptor 4

UR - https://www.scopus.com/pages/publications/84902655964

U2 - 10.1586/1744666X.2014.913481

DO - 10.1586/1744666X.2014.913481

M3 - Review article

C2 - 24898361

AN - SCOPUS:84902655964

SN - 1744-666X

VL - 10

SP - 875

EP - 884

JO - Expert Review of Clinical Immunology

JF - Expert Review of Clinical Immunology

IS - 7

ER -

Evidence-based feeding strategies before and after the development of necrotizing enterocolitis

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Keywords

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