The book will provide a detailed evidence-based approach to key issues in the pathophysiology, diagnosis, and management of patients with concurrent medical issues. It will provide a clinical focus with practical advice on the prevention, diagnosis, and treatment of heart disease supported by an expert's summary, without duplicating other texts. Each chapter will be structured similarly in the following sections: (1) Introduction, (2) Pathophysiology, (3) Diagnosis (4) Management (5) Key Points, (6) Summary of the key guidelines from professional societies where available. The recommendations will have a firm background in the AHA/ACC or ESC recommendations for the management of patients. The intention is to create a comprehensive book rather than a pocketbook or manual. We hope this book will serve as an up to date reference for the practicing clinician. Each of the approximately 40 chapters will have at most 5000 words and 5 -7 high quality figures or illustrations each. Only the highest quality authors will be recruited from the United States and Europe. The emphasis will be on depth of information yet ease of access. This necessitates an approach whereby not a single word, sentence or page of the book will be wasted. Brief where it needs to be brief, detailed where detail is required, this will be a true all-encompassing clinician reference.