Evaluation of two new bifunctional chelates for radiolabeling a parathyroid-specific monoclonal antibody with In-111

S. W. Schwarz, C. J. Mathias, J. Y. Sun, W. G. Dilley, S. A. Wells, A. E. Martell, M. J. Welch

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16 Scopus citations

Abstract

BB5-G1, a monoclonal antibody specific for human parathyroid cell membrane antigen was conjugated with two new ligands, BrMe2HBED and BrφHBED and radiolabeled with 111In. We have compared the biodistribution of 111In-labeled BBS using the new ligands to conventionally labeled (125I-labeled and 111In-DTPA-labeled) BBS in a nude mouse model. Both 111In-BrMe2HBED-BB5 and 111In-BrφHBED-BB5 attained high parathyroid-to-blood and parathyroid-to-muscle ratios by 72-96 h. 111In-BrφHBED-BB5 showed lower %ID/g than 111In-BrMe2HBED-BB5 in the clearance organs, the liver and kidney; renal activity had cleared significantly by 120 h. This work suggests that 111In-BrφHBED-BB5 offers improved in vivo behavior and may be useful as a radiopharmaceutical for localizing parathyroid tissue.

Original languageEnglish
Pages (from-to)477-481
Number of pages5
JournalInternational Journal of Radiation Applications and Instrumentation.
Volume18
Issue number5
DOIs
StatePublished - 1991

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