BB5-G1, a monoclonal antibody specific for human parathyroid cell membrane antigen was conjugated with two new ligands, BrMe2HBED and BrφHBED and radiolabeled with 111In. We have compared the biodistribution of 111In-labeled BBS using the new ligands to conventionally labeled (125I-labeled and 111In-DTPA-labeled) BBS in a nude mouse model. Both 111In-BrMe2HBED-BB5 and 111In-BrφHBED-BB5 attained high parathyroid-to-blood and parathyroid-to-muscle ratios by 72-96 h. 111In-BrφHBED-BB5 showed lower %ID/g than 111In-BrMe2HBED-BB5 in the clearance organs, the liver and kidney; renal activity had cleared significantly by 120 h. This work suggests that 111In-BrφHBED-BB5 offers improved in vivo behavior and may be useful as a radiopharmaceutical for localizing parathyroid tissue.
|Number of pages||5|
|Journal||International Journal of Radiation Applications and Instrumentation.|
|State||Published - 1991|