Evaluation of total body weight versus adjusted body weight voriconazole dosing in obese patients

Elizabeth Diller; Tamara Krekel; Andrej Spec; Jeff Klaus

doi:10.1128/AAC.02460-20

Evaluation of total body weight versus adjusted body weight voriconazole dosing in obese patients

Elizabeth Diller, Tamara Krekel, Andrej Spec, Jeff Klaus

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

This retrospective single-center study of a cohort of adult patients who received voriconazole with a steady-state trough concentration measured during therapy evaluated the rate of therapeutic trough attainment using adjusted body weight (AdjBW)-based and total body weight (TBW)-based dosing in overweight and obese patients. Of the 130 patients included, 45 patients received TBW-based dosing and 85 patients received AdjBW-based dosing. Therapeutic trough attainment was significantly improved with AdjBW-based dosing compared to TBW-based dosing (64.7% versus 46.7%; P=0.047).

Original language	English
Article number	e02460-20
Journal	Antimicrobial agents and chemotherapy
Volume	65
Issue number	7
DOIs	https://doi.org/10.1128/AAC.02460-20
State	Published - Jul 2021

Keywords

Anti-infection agents
Antifungal therapy
Azole antifungals
Azoles
Drug monitoring
Fungal infections
Obesity
Therapeutic drug monitoring
Voriconazole

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10.1128/AAC.02460-20

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title = "Evaluation of total body weight versus adjusted body weight voriconazole dosing in obese patients",

abstract = "This retrospective single-center study of a cohort of adult patients who received voriconazole with a steady-state trough concentration measured during therapy evaluated the rate of therapeutic trough attainment using adjusted body weight (AdjBW)-based and total body weight (TBW)-based dosing in overweight and obese patients. Of the 130 patients included, 45 patients received TBW-based dosing and 85 patients received AdjBW-based dosing. Therapeutic trough attainment was significantly improved with AdjBW-based dosing compared to TBW-based dosing (64.7% versus 46.7%; P=0.047).",

keywords = "Anti-infection agents, Antifungal therapy, Azole antifungals, Azoles, Drug monitoring, Fungal infections, Obesity, Therapeutic drug monitoring, Voriconazole",

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AB - This retrospective single-center study of a cohort of adult patients who received voriconazole with a steady-state trough concentration measured during therapy evaluated the rate of therapeutic trough attainment using adjusted body weight (AdjBW)-based and total body weight (TBW)-based dosing in overweight and obese patients. Of the 130 patients included, 45 patients received TBW-based dosing and 85 patients received AdjBW-based dosing. Therapeutic trough attainment was significantly improved with AdjBW-based dosing compared to TBW-based dosing (64.7% versus 46.7%; P=0.047).

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KW - Antifungal therapy

KW - Azole antifungals

KW - Azoles

KW - Drug monitoring

KW - Fungal infections

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Evaluation of total body weight versus adjusted body weight voriconazole dosing in obese patients

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