Evaluation of pediatric epigenetic clocks across multiple tissues

on behalf of program collaborators for Environmental influences on Child Health Outcomes, Fang Fang, Linran Zhou, Wei Perng, Carmen J. Marsit, Anna K. Knight, Andres Cardenas, Max T. Aung, Marie France Hivert, Izzuddin M. Aris, Jaclyn M. Goodrich, Alicia K. Smith, Abigail Gaylord, Rebecca C. Fry, Emily Oken, George O’Connor, Douglas M. Ruden, Leonardo Trasande, Julie B. Herbstman, Carlos A. CamargoNicole R. Bush, Anne L. Dunlop, Dana M. Dabelea, Margaret R. Karagas, Carrie V. Breton, Carole Ober, Todd M. Everson, Grier P. Page, Christine Ladd-Acosta, P. B. Smith, L. K. Newby, L. P. Jacobson, D. J. Catellier, R. Gershon, D. Cella, F. R. Laham, J. M. Mansbach, S. Wu, J. M. Spergel, J. C. Celedón, H. T. Puls, S. J. Teach, S. C. Porter, I. Y. Waynik, S. S. Iyer, M. E. Samuels-Kalow, A. D.Thompson, M. D. Stevenson, C. S. Bauer, N. R. Inhofe, M. Boos, C. G. Macias, J. Gern, D. Jackson, L. Bacharier, M. Kattan, R. Wood, K. Rivera-Spoljaric, L. Bacharier, T. Bastain, S. Farzan, R. Habre, C. Karr, F. Tylavsky, A. Mason, Q. Zhao, S. Sathyanarayana, N. Bush, K. Z. LeWinn, B. Lester, B. Carter, S. Pastyrnak, C. Neal, L. Smith, J. Helderman, C. McEvoy, R. Tepper, K. Lyall, H. Volk, R. Schmidt, L. Croen, M. O’Shea, R. Vaidya, R. Obeid, C. Rollins, K. Bear, S. Pastyrnak, M. Lenski, R. Singh, M. Msall, J. Frazier, S. Gogcu, A. Montgomery, K. Kuban, L. Douglass, H. Jara, R. Joseph, J. M. Kerver, F. Perera

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Background: Epigenetic clocks are promising tools for assessing biological age. We assessed the accuracy of pediatric epigenetic clocks in gestational and chronological age determination. Results: Our study used data from seven tissue types on three DNA methylation profiling microarrays and found that the Knight and Bohlin clocks performed similarly for blood cells, while the Lee clock was superior for placental samples. The pediatric-buccal-epigenetic clock performed the best for pediatric buccal samples, while the Horvath clock is recommended for children's blood cell samples. The NeoAge clock stands out for its unique ability to predict post-menstrual age with high correlation with the observed age in infant buccal cell samples. Conclusions: Our findings provide valuable guidance for future research and development of epigenetic clocks in pediatric samples, enabling more accurate assessments of biological age.

Original languageEnglish
Article number142
JournalClinical Epigenetics
Volume15
Issue number1
DOIs
StatePublished - Dec 2023

Keywords

  • DNA methylation
  • Early childhood chronological age
  • Epigenetic clock
  • Gestational age

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