Evaluation of Nonalcoholic Fatty Liver Disease in Pediatric Patients with Inflammatory Bowel Disease

Mallory E. Cohen, Parakkal Deepak, Geetika Khanna, Charles M. Samson

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Adult studies demonstrate the co-existence of nonalcoholic fatty liver disease (NAFLD) and inflammatory bowel disease (IBD) without traditional risk factors. Data in children with IBD are lacking. Here, we sought to establish the prevalence of NAFLD in a single-center pediatric IBD cohort, and identify potential risk factors. After institutional review board approval, we enrolled children with IBD who underwent routine abdominal magnetic resonance enterography. Proton density fat fraction (PDFF) was then estimated on magnetic resonance enterography. A total of 83 patients with IBD were identified and PDFF maps completed. Five (6%) were found to have PDFF >5%, meeting criteria for NAFLD. Compared to the patients with IBD without NAFLD, none of the evaluated risk factors including age, sex, diagnosis, time since diagnosis, medication, median alanine aminotransferase, and weight status were statistically significant. Our findings demonstrate the occult nature of NAFLD in pediatric IBD. The prevalence is not at variance with what is expected in general teenage populations.

Original languageEnglish
Pages (from-to)574-578
Number of pages5
JournalJournal of pediatric gastroenterology and nutrition
Volume72
Issue number4
DOIs
StatePublished - Apr 1 2021

Keywords

  • inflammatory bowel disease
  • magnetic resonance enterography
  • nonalcoholic fatty liver disease
  • proton density fat fraction

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