Evaluation of Enoxaparin Dosing as a Risk Factor for Bleeding in Lung Transplant Recipients

Amelia K. Sofjan, Jennifer A. Iuppa, K. Bennett Bain, Eli N. Deal, Chad A. Witt, Ramsey R. Hachem, Roger D. Yusen

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Background: Lung transplant recipients commonly develop complications that lead to anticoagulation. Standard FDA-approved enoxaparin dosing in this population results in a high incidence of above-goal anti-Xa levels, but its association with bleeding remains unclear. Objective: To evaluate the association between enoxaparin dosing and bleeding in lung transplant recipients and assess the relationship between dosing and anti-Xa levels. Methods: We conducted a single-center retrospective cohort study of adult lung transplant recipients who received therapeutic enoxaparin between 2000 and 2012 at a tertiary academic center. We dichotomized enoxaparin dosing regimens into standard dose (FDA-approved doses with a 10% rounding margin) and reduced dose. Clinicians ordered anti-Xa levels as deemed clinically appropriate. The primary outcome was major bleeding or clinically relevant nonmajor bleeding. Results: Of 222 patients treated with enoxaparin, 33 (14.9%) had bleeding events, of which half (17/33) were major. Bleeding occurred in 25/146 (17.1%) patients who received standard-dose enoxaparin versus 8/76 (10.5%) patients who received reduced-dose enoxaparin (P = 0.190). Multiple logistic regression demonstrated an independent association between standard-dose enoxaparin and bleeding, after adjusting for confounders (adjusted odds ratio = 3.04; 95% CI = 1.14-8.10). The median enoxaparin dose in patients with above-goal versus at-goal anti-Xa levels was 0.89 versus 0.76 mg/kg every 12 hours; P = 0.006. However, doses yielding at-goal anti-Xa levels had an interquartile range of 0.67 to 0.90 mg/kg, which overlapped with doses yielding above- and below-goal anti-Xa levels. Conclusions: Enoxaparin dose reduction and anti-Xa level monitoring can improve drug safety and facilitate individualized dose optimization in lung transplant recipients.

Original languageEnglish
Pages (from-to)824-831
Number of pages8
JournalAnnals of Pharmacotherapy
Volume50
Issue number10
DOIs
StatePublished - Oct 1 2016

Keywords

  • anticoagulants
  • drug monitoring
  • enoxaparin
  • factor Xa
  • hemorrhage
  • heparin
  • low molecular weight
  • lung transplantation
  • postoperative complications

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