Evaluation of co-morbidity indices in patients admitted for Chronic Obstructive Pulmonary Disease

Richard G. Pinckney, R. O'Brien, J. F. Piccirillo, B. Littenberg

Research output: Contribution to journalArticle

8 Scopus citations


Background. There is limited and conflicting information on the use of co-morbidity instruments to predict mortality in patients with chronic obstructive pulmonary disease (COPD). Methods. We sought to test the validity of the Charlson Index and another co-morbidity instrument, the Adult co-morbidity evaluation 27 (ACE-27), in patients admitted with COPD exacerbations. Co-morbidity scores were obtained by chart review. Information on mortality was retrieved from the Social Security Death Index. We examined the predictive validity of the Charlson and the ACE-27 using survival analysis. Results. There were 112 patients eligible for the study. The ACE-27 but not the Charlson predicted survival, after adjusting for age, gender, and smoking history in Cox regression, hazard ratio (95% CI) of 1.99 (1.17-3.39). Conclusions. This study confirms earlier findings that the Charlson Index is not a reliable predictor of mortality in patients with COPD. However, the ACE-27 appears to be useful for predicting survival in this study.

Original languageEnglish
Pages (from-to)209-212
Number of pages4
JournalMonaldi Archives for Chest Disease - Pulmonary Series
Issue number4
StatePublished - Jan 1 2004
Externally publishedYes


  • Chronic obstructive
  • Co-Morbidity
  • Prognosis
  • Pulmonary disease
  • Risk adjustment

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