Evaluation of an MRI-Guided PET Image Reconstruction Approach With Adaptive Penalization Strength

Jorge Cabello, Michael T. Jurkiewicz, Andrea Andrade, Tammie L.S. Benzinger, Hongyu An, Udunna C. Anazodo

Research output: Contribution to journalArticlepeer-review


MRI-guided (MRIg) PET reconstruction can potentially reduce noise and increase spatial resolution compared to standard clinical OSEM image quality. However, to adjust for the desired image quality, the balance between measured data and prior information usually requires manual tuning. This work presents an adaptive method to automatically control the influence of the MRI information on the PET emission data using maximum a posteriori (MAP) image reconstruction, robust against a wide range of counts. The method was evaluated on different static brain PET datasets using 18F-FDG, 18F-Florbetapir and 11C-PiB, acquired in a simultaneous PET/MRI scanner and a PET/CT scanner, followed by an MRI scan. Noise in gray and white matter was measured for a wide range of statistics. Furthermore, noise and quantification accuracy were analysed in different cortical and subcortical brain regions with different levels of tracer uptake, and at different levels of counts. Results demonstrated consistent improved image quality in terms of noise and spatial resolution with MRIg-MAP reconstruction compared to OSEM. Additionally, it was shown that the number of collected counts could be reduced by ˜1.6-2.3x using MRIg-MAP reconstruction compared to OSEM, without increasing the noise significantly, either by reducing the scan time or injected activity. In conclusion, we presented a novel method to adaptively balance the influence of the anatomical information on the emission data for MRIg-MAP reconstruction, which showed image quality improvements compared to OSEM for different radiotracers, at different levels of counts, and applicable to simultaneous and sequential PET-MRI scans.

Original languageEnglish
Pages (from-to)1
Number of pages1
JournalIEEE Transactions on Radiation and Plasma Medical Sciences
StateAccepted/In press - 2024


  • 18F-FDG-epilepsy
  • adaptive spatially-variant hyperparameter
  • Biomedical imaging
  • Image quality
  • Image reconstruction
  • Magnetic resonance imaging
  • MAP
  • MRI-guided
  • PET
  • Positron emission tomography
  • Reconstruction algorithms
  • Spatial resolution
  • tau-imaging


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