@article{bf6dc1bb0ecc4262ba2fad5627a07390,
title = "Evaluation of adenovirus capsid labeling versus transgene expression",
abstract = "Adenoviral vectors have been utilized for a variety of gene therapy applications. Our group has incorporated bioluminescent, fluorographic reporters, and/or suicide genes within the adenovirus genome for analytical and/or therapeutic purposes. These molecules have also been incorporated as capsid components. Recognizing that incorporations at either locale yield potential advantages and disadvantages, our report evaluates the benefits of transgene incorporation versus capsid incorporation. To this end, we have genetically incorporated firefly luciferase within the early region 3 or at minor capsid protein IX and compared vector functionality by means of reporter readout.",
author = "Jing Li and Aiman Fatima and Svetlana Komarova and Hideyo Ugai and Priyanka Uprety and Roth, {Justin C.} and Minghui Wang and Oster, {Robert A.} and Curiel, {David T.} and Matthews, {Qiana L.}",
note = "Funding Information: This work was supported by grants from the National Institutes of Health: Grants 3 R01 CA111569-05S (Dr. David T. Curiel). This work was also supported by UAB{\textquoteright}s Small Animal Imaging Shared Facility (P30CA013148). The authors would also like to acknowledge Drs. Anton V. Borovjagin, Erin E. Thacker, and Hongju Wu for their critical reading of the manuscript. The authors would like to thank Karri D. Folks for her assistance with the in vivo mouse imaging.",
year = "2010",
doi = "10.1186/1743-422X-7-21",
language = "English",
volume = "7",
journal = "Virology Journal",
issn = "1743-422X",
}