TY - JOUR
T1 - Evaluation of a structure-based statine cyclic diamino amide encoded combinatorial library against plasmepsin II and cathepsin D
AU - Carroll, Carolyn Di Ianni
AU - Johnson, Theodore O.
AU - Tao, Shewei
AU - Lauri, Giorgio
AU - Orlowski, Marc
AU - Gluzman, Ilya Y.
AU - Goldberg, Daniel E.
AU - Dolle, Roland E.
PY - 1998/11/17
Y1 - 1998/11/17
N2 - A structure-based 18,900-member combinatorial library was synthesized containing a statine template and three cyclic diamino acids as potential P1', P2-P4 surrogates. Evaluation of this encoded library against two aspartyl proteases, plasmepsin II and cathepsin D, led to the identification of selective inhibitors for each enzyme.
AB - A structure-based 18,900-member combinatorial library was synthesized containing a statine template and three cyclic diamino acids as potential P1', P2-P4 surrogates. Evaluation of this encoded library against two aspartyl proteases, plasmepsin II and cathepsin D, led to the identification of selective inhibitors for each enzyme.
UR - http://www.scopus.com/inward/record.url?scp=0032542040&partnerID=8YFLogxK
U2 - 10.1016/S0960-894X(98)00554-X
DO - 10.1016/S0960-894X(98)00554-X
M3 - Article
C2 - 9873703
AN - SCOPUS:0032542040
SN - 0960-894X
VL - 8
SP - 3203
EP - 3206
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 22
ER -