Evaluation of 3 T pelvic MRI imaging in prostate cancer patients receiving post-prostatectomy IMRT

Vivek Verma, Ling Chen, Jeff M. Michalski, Yanle Hu, Wenjun Zhang, Kathryn Robinson, Shivam Verma, Laura Eschen, Sandra Fergus, Dan Mullen, Seth Strope, Robert Grubb, Hiram A. Gay

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Purpose: The purpose of the study was to evaluate the utility of a 3 T pelvic magnetic resonance imaging (MRI) in detecting a local recurrence in post-prostatectomy prostate cancer patients prior to receiving adjuvant or salvage intensity-modulated radiation therapy (IMRT). Methods: Ninety prostate cancer patients status post-prostatectomy with rising prostate-specific antigen (PSA) had a 3 T pelvic MRI prior to IMRT. The following variables were analyzed for predicting positive findings on MRI: initial presenting and initial post-op PSA, PSA at the time of imaging, PSA velocity, surgical margins, Gleason score, pathological stage, pre-RT digital rectal examination, and type of surgical prostatectomy. Results: The only significant variable predictive of a positive MRI was positive margins. Specifically, 15 of 46 (33 %) patients with positive margins had a positive MRI, while 5 of 44 (11 %) patients with negative margins had a positive MRI. In the MRI positive group, the location of the positive findings on MRI corresponded with the pathology report in 9 of 12 (75 %) cases. Conclusion: Post-prostatectomy patients with pathologic positive margins are three times more likely to have positive findings on a 3 T MRI.

Original languageEnglish
Pages (from-to)69-75
Number of pages7
JournalWorld Journal of Urology
Issue number1
StatePublished - Jan 2014


  • 3 T pelvic MRI
  • Adjuvant radiotherapy
  • Post-prostatectomy IMRT
  • Prostate cancer
  • Salvage radiotherapy


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