Evaluating the correlation of the impairment between skeletal muscle and heart using MRI in a spontaneous type 2 diabetes mellitus rhesus monkey model

Yushu Chen; Wen Zeng; Wei Chen; Yu Zhang; Tong Zhu; Jiayu Sun; Zhigang Liang; Lei Wang; Zunyuan Yang; Bing Wu; Bin Song; Fangtong Wang; Yinan Liang; Li Gong; Jie Zheng; Fabao Gao

doi:10.1007/s00592-019-01460-0

Evaluating the correlation of the impairment between skeletal muscle and heart using MRI in a spontaneous type 2 diabetes mellitus rhesus monkey model

Yushu Chen, Wen Zeng, Wei Chen, Yu Zhang, Tong Zhu, Jiayu Sun, Zhigang Liang, Lei Wang, Zunyuan Yang, Bing Wu, Bin Song, Fangtong Wang, Yinan Liang, Li Gong, Jie Zheng, Fabao Gao

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Abstract

Aims: To investigate the correlation of impairment in skeletal muscle and heart in spontaneous type 2 diabetes mellitus (T2DM) rhesus monkeys using magnetic resonance image (MRI). Methods: Fifteen T2DM monkeys and fourteen healthy control (HC) monkeys were included. The microcirculation of skeletal muscle [skeletal muscle blood flow (SMBF), skeletal muscle oxygen extraction fraction (SMOEF)] and the function and strain of heart were evaluated by MRI. Three regions of interests were chosen on the soleus muscle (SOL), gastrocnemius muscle (GAS) and tibialis anterior muscle (TA) for image analysis. Results: Eight T2DM monkeys and eight HC monkeys were obtained the full data. The SMBF reserves and SMOEF reserves were found significantly decreased in T2DM during inflation in SOL, GAS and TA muscles (all p < 0.05), and the SMBF reserves decreased during hyperemia in GAS and TA muscles (all p < 0.05). In these monkeys, the global peak longitudinal strain (longitudinal PS), peak systolic longitudinal strain rate (longitudinal PSSR) and peak diastolic longitudinal strain rate (longitudinal PDSR) were seen significantly different in T2DM compared to HC monkeys (all p < 0.05). The longitudinal PSSR was found negatively correlated with SMBF reserves in SOL, GAS and TA during inflation in all monkeys. Conclusions: The impaired microcirculation of skeletal muscle and the myocardial deformation were found in T2DM monkeys with normal ejection fraction. And a negative correlation was existed in the longitudinal PSSR and the SMBF reserves.

Original language	English
Pages (from-to)	673-679
Number of pages	7
Journal	Acta Diabetologica
Volume	57
Issue number	6
DOIs	https://doi.org/10.1007/s00592-019-01460-0
State	Published - Jun 1 2020

Keywords

Diabetes
Impairment
MRI
Microcirculation
Monkey

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10.1007/s00592-019-01460-0

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Chen, Y., Zeng, W., Chen, W., Zhang, Y., Zhu, T., Sun, J., Liang, Z., Wang, L., Yang, Z., Wu, B., Song, B., Wang, F., Liang, Y., Gong, L., Zheng, J., & Gao, F. (2020). Evaluating the correlation of the impairment between skeletal muscle and heart using MRI in a spontaneous type 2 diabetes mellitus rhesus monkey model. Acta Diabetologica, 57(6), 673-679. https://doi.org/10.1007/s00592-019-01460-0

@article{626d9967d8ef4365bb83fb7af958f6ce,

title = "Evaluating the correlation of the impairment between skeletal muscle and heart using MRI in a spontaneous type 2 diabetes mellitus rhesus monkey model",

abstract = "Aims: To investigate the correlation of impairment in skeletal muscle and heart in spontaneous type 2 diabetes mellitus (T2DM) rhesus monkeys using magnetic resonance image (MRI). Methods: Fifteen T2DM monkeys and fourteen healthy control (HC) monkeys were included. The microcirculation of skeletal muscle [skeletal muscle blood flow (SMBF), skeletal muscle oxygen extraction fraction (SMOEF)] and the function and strain of heart were evaluated by MRI. Three regions of interests were chosen on the soleus muscle (SOL), gastrocnemius muscle (GAS) and tibialis anterior muscle (TA) for image analysis. Results: Eight T2DM monkeys and eight HC monkeys were obtained the full data. The SMBF reserves and SMOEF reserves were found significantly decreased in T2DM during inflation in SOL, GAS and TA muscles (all p < 0.05), and the SMBF reserves decreased during hyperemia in GAS and TA muscles (all p < 0.05). In these monkeys, the global peak longitudinal strain (longitudinal PS), peak systolic longitudinal strain rate (longitudinal PSSR) and peak diastolic longitudinal strain rate (longitudinal PDSR) were seen significantly different in T2DM compared to HC monkeys (all p < 0.05). The longitudinal PSSR was found negatively correlated with SMBF reserves in SOL, GAS and TA during inflation in all monkeys. Conclusions: The impaired microcirculation of skeletal muscle and the myocardial deformation were found in T2DM monkeys with normal ejection fraction. And a negative correlation was existed in the longitudinal PSSR and the SMBF reserves.",

keywords = "Diabetes, Impairment, MRI, Microcirculation, Monkey",

author = "Yushu Chen and Wen Zeng and Wei Chen and Yu Zhang and Tong Zhu and Jiayu Sun and Zhigang Liang and Lei Wang and Zunyuan Yang and Bing Wu and Bin Song and Fangtong Wang and Yinan Liang and Li Gong and Jie Zheng and Fabao Gao",

note = "Funding Information: This study was funded by the National Natural Science Foundation of China (Grant Numbers 81520108014, 81771800, 81829003) and the State{\textquoteright}s Key Project of Research and Development Plan of China (2016YFA0201402). Publisher Copyright: {\textcopyright} 2020, Springer-Verlag Italia S.r.l., part of Springer Nature.",

year = "2020",

month = jun,

day = "1",

doi = "10.1007/s00592-019-01460-0",

language = "English",

volume = "57",

pages = "673--679",

journal = "Acta Diabetologica",

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Chen, Y, Zeng, W, Chen, W, Zhang, Y, Zhu, T, Sun, J, Liang, Z, Wang, L, Yang, Z, Wu, B, Song, B, Wang, F, Liang, Y, Gong, L, Zheng, J & Gao, F 2020, 'Evaluating the correlation of the impairment between skeletal muscle and heart using MRI in a spontaneous type 2 diabetes mellitus rhesus monkey model', Acta Diabetologica, vol. 57, no. 6, pp. 673-679. https://doi.org/10.1007/s00592-019-01460-0

TY - JOUR

T1 - Evaluating the correlation of the impairment between skeletal muscle and heart using MRI in a spontaneous type 2 diabetes mellitus rhesus monkey model

AU - Chen, Yushu

AU - Zeng, Wen

AU - Chen, Wei

AU - Zhang, Yu

AU - Zhu, Tong

AU - Sun, Jiayu

AU - Liang, Zhigang

AU - Wang, Lei

AU - Yang, Zunyuan

AU - Wu, Bing

AU - Song, Bin

AU - Wang, Fangtong

AU - Liang, Yinan

AU - Gong, Li

AU - Zheng, Jie

AU - Gao, Fabao

N1 - Funding Information: This study was funded by the National Natural Science Foundation of China (Grant Numbers 81520108014, 81771800, 81829003) and the State’s Key Project of Research and Development Plan of China (2016YFA0201402). Publisher Copyright: © 2020, Springer-Verlag Italia S.r.l., part of Springer Nature.

PY - 2020/6/1

Y1 - 2020/6/1

N2 - Aims: To investigate the correlation of impairment in skeletal muscle and heart in spontaneous type 2 diabetes mellitus (T2DM) rhesus monkeys using magnetic resonance image (MRI). Methods: Fifteen T2DM monkeys and fourteen healthy control (HC) monkeys were included. The microcirculation of skeletal muscle [skeletal muscle blood flow (SMBF), skeletal muscle oxygen extraction fraction (SMOEF)] and the function and strain of heart were evaluated by MRI. Three regions of interests were chosen on the soleus muscle (SOL), gastrocnemius muscle (GAS) and tibialis anterior muscle (TA) for image analysis. Results: Eight T2DM monkeys and eight HC monkeys were obtained the full data. The SMBF reserves and SMOEF reserves were found significantly decreased in T2DM during inflation in SOL, GAS and TA muscles (all p < 0.05), and the SMBF reserves decreased during hyperemia in GAS and TA muscles (all p < 0.05). In these monkeys, the global peak longitudinal strain (longitudinal PS), peak systolic longitudinal strain rate (longitudinal PSSR) and peak diastolic longitudinal strain rate (longitudinal PDSR) were seen significantly different in T2DM compared to HC monkeys (all p < 0.05). The longitudinal PSSR was found negatively correlated with SMBF reserves in SOL, GAS and TA during inflation in all monkeys. Conclusions: The impaired microcirculation of skeletal muscle and the myocardial deformation were found in T2DM monkeys with normal ejection fraction. And a negative correlation was existed in the longitudinal PSSR and the SMBF reserves.

AB - Aims: To investigate the correlation of impairment in skeletal muscle and heart in spontaneous type 2 diabetes mellitus (T2DM) rhesus monkeys using magnetic resonance image (MRI). Methods: Fifteen T2DM monkeys and fourteen healthy control (HC) monkeys were included. The microcirculation of skeletal muscle [skeletal muscle blood flow (SMBF), skeletal muscle oxygen extraction fraction (SMOEF)] and the function and strain of heart were evaluated by MRI. Three regions of interests were chosen on the soleus muscle (SOL), gastrocnemius muscle (GAS) and tibialis anterior muscle (TA) for image analysis. Results: Eight T2DM monkeys and eight HC monkeys were obtained the full data. The SMBF reserves and SMOEF reserves were found significantly decreased in T2DM during inflation in SOL, GAS and TA muscles (all p < 0.05), and the SMBF reserves decreased during hyperemia in GAS and TA muscles (all p < 0.05). In these monkeys, the global peak longitudinal strain (longitudinal PS), peak systolic longitudinal strain rate (longitudinal PSSR) and peak diastolic longitudinal strain rate (longitudinal PDSR) were seen significantly different in T2DM compared to HC monkeys (all p < 0.05). The longitudinal PSSR was found negatively correlated with SMBF reserves in SOL, GAS and TA during inflation in all monkeys. Conclusions: The impaired microcirculation of skeletal muscle and the myocardial deformation were found in T2DM monkeys with normal ejection fraction. And a negative correlation was existed in the longitudinal PSSR and the SMBF reserves.

KW - Diabetes

KW - Impairment

KW - MRI

KW - Microcirculation

KW - Monkey

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U2 - 10.1007/s00592-019-01460-0

DO - 10.1007/s00592-019-01460-0

M3 - Article

C2 - 31938886

AN - SCOPUS:85078589216

SN - 0940-5429

VL - 57

SP - 673

EP - 679

JO - Acta Diabetologica

JF - Acta Diabetologica

IS - 6

ER -

Evaluating the correlation of the impairment between skeletal muscle and heart using MRI in a spontaneous type 2 diabetes mellitus rhesus monkey model

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