Abstract
DNA polymerase δ (Pol δ) is the DNA synthetic workhorse in the eukaryotic cell. Besides its essential function on the lagging strand of the DNA replication fork, this enzyme also functions during DNA recombinational processes, various DNA repair processes, and even during damage-induced mutagenesis in the cell. It can accomplish these various tasks because the enzyme is processive, has high fidelity, and has the capacity to carry out strand displacement synthesis. Like the other essential DNA polymerases, Pol δ and Pol δ, Pol δ is a B-family DNA polymerase, and the catalytic subunit is part of a multisubunit complex.
| Original language | English |
|---|---|
| Title of host publication | Encyclopedia of Biological Chemistry |
| Subtitle of host publication | Second Edition |
| Publisher | Elsevier Inc. |
| Pages | 245-248 |
| Number of pages | 4 |
| ISBN (Electronic) | 9780123786319 |
| ISBN (Print) | 9780123786302 |
| DOIs | |
| State | Published - Feb 15 2013 |
Keywords
- Base excison repair
- DNA damage
- DNA polymerase
- DNA recombination
- DNA repair
- DNA replication
- Eukaryotic
- Exonuclease
- Mutagenesis
- PCNA
- Strand displacement synthesis