@article{83f5e1d3daad485ba508da606012f501,
title = "ETV5 regulates ductal morphogenesis with Sox9 and is critical for regeneration from pancreatitis",
abstract = "Background: The plasticity of pancreatic acinar cells to undergo acinar to ductal metaplasia (ADM) has been demonstrated to contribute to the regeneration of the pancreas in response to injury. Sox9 is critical for ductal cell fate and important in the formation of ADM, most likely in concert with a complex hierarchy of, as yet, not fully elucidated transcription factors. Results: By using a mouse model of acute pancreatitis and three dimensional organoid culture of primary pancreatic ductal cells, we herein characterize the Ets-transcription factor Etv5 as a pivotal regulator of ductal cell identity and ADM that acts upstream of Sox9 and is essential for Sox9 expression in ADM. Loss of Etv5 is associated with increased severity of acute pancreatitis and impaired ADM formation leading to delayed tissue regeneration and recovery in response to injury. Conclusions: Our data provide new insights in the regulation of ADM with implications in our understanding of pancreatic homeostasis, pancreatitis and epithelial plasticity. Developmental Dynamics 247:854–866, 2018.",
keywords = "Etv5, Sox9, acinar ductal metaplasia, pancreatitis",
author = "Das, {Koushik K.} and Steffen Heeg and Pitarresi, {Jason R.} and Maximilian Reichert and Basil Bakir and Shigetsugu Takano and Kopp, {Janel L.} and Anja Wahl-Feuerstein and Philip Hicks and Maike Sander and Rustgi, {Anil K.}",
note = "Funding Information: The authors have no disclosures. S.T., M.R., and A.K.R. were funded by the NIH, K.D., J.K.L. and M.S. were funded by NIH/ NIDDK, M.R. was funded by the National Pancreas Foundation, S.H. was funded by the Deutsche Krebshilfe, M.R. and A.N. were funded by the Max Eder Program, M.R. received an AGA-Actavis Research Award in Pancreatic Disorders, S.T. was funded by the Honjo International Scholarship, J.L.K. received a JDRF Advanced Postdoctoral Fellowship, and A.K.R. was funded by the NIH/NIDDK P30-DK050306 Center for Molecular Studies in Digestive and Liver Diseases (Molecular Pathology and Imaging, Molecular Biology/ Gene Expression, Cell Culture, and Transgenic and Chimeric Mouse Cores), and American Cancer Society Grant RP-10-033-01-CCE. Funding Information: The authors have no disclosures. S.T., M.R., and A.K.R. were funded by the NIH, K.D., J.K.L. and M.S. were funded by NIH/NIDDK, M.R. was funded by the National Pancreas Foundation, S.H. was funded by the Deutsche Krebshilfe, M.R. and A.N. were funded by the Max Eder Program, M.R. received an AGA-Actavis Research Award in Pancreatic Disorders, S.T. was funded by the Honjo International Scholarship, J.L.K. received a JDRF Advanced Postdoctoral Fellowship, and A.K.R. was funded by the NIH/NIDDK P30-DK050306 Center for Molecular Studies in Digestive and Liver Diseases (Molecular Pathology and Imaging, Molecular Biology/Gene Expression, Cell Culture, and Transgenic and Chimeric Mouse Cores), and American Cancer Society Grant RP-10-033-01-CCE. Funding Information: Grant sponsor: NIH; Grant number: R01 DK060694; Grant sponsor: NIH/NIDDK; Grant numbers: T32-DK007066, NIH-F32CA136124, NIH-R21CA194839, NIH-R01 DK078803; Grant sponsor: National Pancreas Foundation; Grant sponsor: Deutsche Krebshilfe; Grant number: 110037; Grant sponsor: Max Eder Program; Grant numbers: 111273, 110972; Grant sponsor: AGA-Actavis Research Award in Pancreatic Disorders; Grant sponsor: NIH/NIDDK P30-DK050306 Center for Molecular Studies in Digestive and Liver Diseases; Grant sponsor: American Cancer Society; Grant number: RP-10-033-01-CCE. †These authors contributed equally to this work. Publisher Copyright: {\textcopyright} 2018 Wiley Periodicals, Inc.",
year = "2018",
month = jun,
doi = "10.1002/dvdy.24626",
language = "English",
volume = "247",
pages = "854--866",
journal = "Developmental Dynamics",
issn = "1058-8388",
number = "6",
}