@inproceedings{6110dfdb2ea040dc99b7671295d3dad5,
title = "ETV5 is required for continuous spermatogenesis in adult mice and may mediate blood-testes barrier function and testicular immune privilege",
abstract = "The transcription factor Ets-variant gene 5 (ETV5) is essential for spermatogonial stem cell (SSC) self-renewal, as the targeted deletion of the Etv5 gene in mice (Etv5-/-) results in only the first wave of spermatogenesis. Reciprocal transplants of neonatal germ cells from wild-type (WT) and Etv5-/- testes were performed to determine the role of ETV5 in Sertoli cells and germ cells. ETV5 appears to be needed in both cell types for normal spermatogenesis. In addition, Etv5-/- recipients displayed increased interstitial inflammation and tubular involution after transplantation. Preliminary studies suggest that the blood-testis barrier (Sertoli-Sertoli tight junctional complex) is abnormal in the Etv5-/- mouse.",
keywords = "ERM, Germ-cell transplantation, Sertoli cell, Spermatogonial stem cell",
author = "Morrow, {Carla M.K.} and Hostetler, {Chris E.} and Griswold, {Mike D.} and Hofmann, {Marie Claude} and Murphy, {Kenneth M.} and Cooke, {Paul S.} and Hess, {Rex A.}",
year = "2007",
month = dec,
doi = "10.1196/annals.1411.005",
language = "English",
isbn = "9781573316934",
series = "Annals of the New York Academy of Sciences",
publisher = "Blackwell Publishing Inc.",
pages = "144--151",
booktitle = "Testicular Chromosome Structure and Gene Expression",
}