ETV5 is required for continuous spermatogenesis in adult mice and may mediate blood-testes barrier function and testicular immune privilege

Carla M.K. Morrow, Chris E. Hostetler, Mike D. Griswold, Marie Claude Hofmann, Kenneth M. Murphy, Paul S. Cooke, Rex A. Hess

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

35 Scopus citations

Abstract

The transcription factor Ets-variant gene 5 (ETV5) is essential for spermatogonial stem cell (SSC) self-renewal, as the targeted deletion of the Etv5 gene in mice (Etv5-/-) results in only the first wave of spermatogenesis. Reciprocal transplants of neonatal germ cells from wild-type (WT) and Etv5-/- testes were performed to determine the role of ETV5 in Sertoli cells and germ cells. ETV5 appears to be needed in both cell types for normal spermatogenesis. In addition, Etv5-/- recipients displayed increased interstitial inflammation and tubular involution after transplantation. Preliminary studies suggest that the blood-testis barrier (Sertoli-Sertoli tight junctional complex) is abnormal in the Etv5-/- mouse.

Original languageEnglish
Title of host publicationTesticular Chromosome Structure and Gene Expression
PublisherBlackwell Publishing Inc.
Pages144-151
Number of pages8
ISBN (Print)9781573316934
DOIs
StatePublished - Dec 2007

Publication series

NameAnnals of the New York Academy of Sciences
Volume1120
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • ERM
  • Germ-cell transplantation
  • Sertoli cell
  • Spermatogonial stem cell

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