Etiology of strokes in children with sickle cell anemia

Michael R. DeBaun, Colin P. Derdeyn, Robert C. McKinstry

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations


The most devastating complication of sickle cell anemia is cerebral infarction, affecting ∼30% of all individuals with sickle cell anemia. Despite being one of the most common causes of stroke in infants and children, the mechansm of cerebral infarction in this population has not been extensively studied and is poorly understood. Multiple, synergistic factors are important in the pathogenesis of stroke including the hemodynamic effects of cerebral arterial occlusive disease, viscosity, chronic and acute anemia and acute medical events. This review focuses on the relationship between these factors in order to provide a foundation for further study of the etiology of strokes in this high-risk population.

Original languageEnglish
Pages (from-to)192-199
Number of pages8
JournalMental Retardation and Developmental Disabilities Research Reviews
Issue number3
StatePublished - 2006


  • Sickle cell disease
  • Stroke


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