TY - JOUR
T1 - Ethosomes and ultradeformable liposomes for transdermal delivery of clotrimazole
T2 - A comparative assessment
AU - Maheshwari, Rahul G.S.
AU - Tekade, Rakesh K.
AU - Sharma, Piyoosh A.
AU - Darwhekar, Gajanan
AU - Tyagi, Abhishek
AU - Patel, Rakesh P.
AU - Jain, Dinesh K.
PY - 2012/4
Y1 - 2012/4
N2 - The objective of work was to formulate, evaluate and compare the transdermal potential of novel vesicular nanocarriers: ethosomes and ultradeformable liposomes, containing clotrimazole (CLT), an anti-fungal bioactive. The ethosomal formulation (ET 4) and ultradeformable liposomal (UL) formulation (TT 3) showed highest entrapment 68.73±1.4% and 55.51±1.7%, optimal nanometric size range 132±9.5nm and 121±9.7nm, and smallest polydispersity index 0.027±0.011 and 0.067±0.009, respectively. The formulation ET 4 provided enhanced transdermal flux 56.25±5.49μg/cm 2/h and decreased the lag time of 0.9h in comparison to TT 3 formulation (50.16±3.84μg/cm 2/h; 1.0h). Skin interaction and FT-IR studies revealed greater penetration enhancing effect of ET 4 than TT 3 formulation. ET 4 formulation also had the highest zone of inhibition (34.6±0.57mm), in contrast to TT 3 formulation (29.6±0.57mm) and marketed cream formulation (19.0±1.00mm) against candidal species. Results suggested ethosomes to be the most proficient carrier system for dermal and transdermal delivery of clotrimazole.
AB - The objective of work was to formulate, evaluate and compare the transdermal potential of novel vesicular nanocarriers: ethosomes and ultradeformable liposomes, containing clotrimazole (CLT), an anti-fungal bioactive. The ethosomal formulation (ET 4) and ultradeformable liposomal (UL) formulation (TT 3) showed highest entrapment 68.73±1.4% and 55.51±1.7%, optimal nanometric size range 132±9.5nm and 121±9.7nm, and smallest polydispersity index 0.027±0.011 and 0.067±0.009, respectively. The formulation ET 4 provided enhanced transdermal flux 56.25±5.49μg/cm 2/h and decreased the lag time of 0.9h in comparison to TT 3 formulation (50.16±3.84μg/cm 2/h; 1.0h). Skin interaction and FT-IR studies revealed greater penetration enhancing effect of ET 4 than TT 3 formulation. ET 4 formulation also had the highest zone of inhibition (34.6±0.57mm), in contrast to TT 3 formulation (29.6±0.57mm) and marketed cream formulation (19.0±1.00mm) against candidal species. Results suggested ethosomes to be the most proficient carrier system for dermal and transdermal delivery of clotrimazole.
KW - Anticandidal efficiency
KW - Atomic force microscopy
KW - Ethosomes
KW - Nanocarriers
KW - Ultradeformable liposomes
UR - https://www.scopus.com/pages/publications/84860343371
U2 - 10.1016/j.jsps.2011.10.001
DO - 10.1016/j.jsps.2011.10.001
M3 - Article
AN - SCOPUS:84860343371
SN - 1319-0164
VL - 20
SP - 161
EP - 170
JO - Saudi Pharmaceutical Journal
JF - Saudi Pharmaceutical Journal
IS - 2
ER -