Ethnicity, sex, and the incidence of congenital heart defects: A report from the National Down Syndrome Project

Sallie B. Freeman, Lora H. Bean, Emily G. Allen, Stuart W. Tinker, Adam Locke, Charlotte Druschel, Charlotte A. Hobbs, Paul A. Romitti, Marjorie H. Royle, Claudine P. Torfs, Kenneth J. Dooley, Stephanie L. Sherman

Research output: Contribution to journalArticle

172 Scopus citations

Abstract

PURPOSE: The population-based National Down Syndrome Project combined epidemiological and molecular methods to study congenital heart defects in Down syndrome. METHODS: Between 2000 and 2004, six sites collected DNA, clinical, and epidemiological information on parents and infants. We used logistic regression to examine factors associated with the most common Down syndrome-associated heart defects. RESULTS: Of 1469 eligible infants, major cardiac defects were present in 44%; atrioventricular septal defect (39%), secundum atrial septal defect (42%), ventricular septal defect (43%), and tetralogy of Fallot (6%). Atrioventricular septal defects showed the most significant sex and ethnic differences with twice as many affected females (odds ratio, 1.93; 95% confidence interval, 1.40-2.67) and, compared with whites, twice as many blacks (odds ratio, 2.06; 95% confidence interval, 1.32-3.21) and half as many Hispanics (odds ratio, 0.48; 95% confidence interval, 0.30-0.77). No associations were found with origin of the nondisjunction error or with the presence of gastrointestinal defects. CONCLUSIONS: Sex and ethnic differences exist for atrioventricular septal defects in Down syndrome. Identification of genetic and environmental risk factors associated with these differences is essential to our understanding of the etiology of congenital heart defects.

Original languageEnglish
Pages (from-to)173-180
Number of pages8
JournalGenetics in Medicine
Volume10
Issue number3
DOIs
StatePublished - Mar 1 2008

Keywords

  • Ancestral informative markers
  • Atrioventricular septal defect
  • Congenital heart defects
  • Down syndrome
  • Ethnicity
  • Gender
  • Maternal age
  • Race
  • Sex
  • Trisomy 21

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    Freeman, S. B., Bean, L. H., Allen, E. G., Tinker, S. W., Locke, A., Druschel, C., Hobbs, C. A., Romitti, P. A., Royle, M. H., Torfs, C. P., Dooley, K. J., & Sherman, S. L. (2008). Ethnicity, sex, and the incidence of congenital heart defects: A report from the National Down Syndrome Project. Genetics in Medicine, 10(3), 173-180. https://doi.org/10.1097/GIM.0b013e3181634867