TY - JOUR
T1 - Estrogens in the breast tissue
T2 - A systematic review
AU - Yaghjyan, Lusine
AU - Colditz, Graham A.
N1 - Funding Information:
Acknowledgments Dr. Graham Colditz is supported by ACS Clinical Research Professorship.
PY - 2011/4
Y1 - 2011/4
N2 - The role of estrogens in breast carcinogenesis has been investigated at the level of whole body (plasma) and cell (molecular, receptors, etc.). Growing attention focused on the breast tissue being an intracrine organ, with potentially important local estrogen production in the breast. However, very little is known about the local breast tissue estrogen levels. Understanding the role of the tissue estrogens in breast carcinogenesis might open new avenues in breast cancer prevention. This systematic review summarizes published studies that measured local estrogen levels in the breast and offers suggestions for strategies to fill gaps in our existing scientific knowledge.
AB - The role of estrogens in breast carcinogenesis has been investigated at the level of whole body (plasma) and cell (molecular, receptors, etc.). Growing attention focused on the breast tissue being an intracrine organ, with potentially important local estrogen production in the breast. However, very little is known about the local breast tissue estrogen levels. Understanding the role of the tissue estrogens in breast carcinogenesis might open new avenues in breast cancer prevention. This systematic review summarizes published studies that measured local estrogen levels in the breast and offers suggestions for strategies to fill gaps in our existing scientific knowledge.
KW - Breast carcinogenesis
KW - Estrogen metabolites
KW - Tissue estrogen metabolism
UR - http://www.scopus.com/inward/record.url?scp=79955757952&partnerID=8YFLogxK
U2 - 10.1007/s10552-011-9729-4
DO - 10.1007/s10552-011-9729-4
M3 - Review article
C2 - 21286801
AN - SCOPUS:79955757952
SN - 0957-5243
VL - 22
SP - 529
EP - 540
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 4
ER -