The role of estrogens in breast carcinogenesis has been investigated at the level of whole body (plasma) and cell (molecular, receptors, etc.). Growing attention focused on the breast tissue being an intracrine organ, with potentially important local estrogen production in the breast. However, very little is known about the local breast tissue estrogen levels. Understanding the role of the tissue estrogens in breast carcinogenesis might open new avenues in breast cancer prevention. This systematic review summarizes published studies that measured local estrogen levels in the breast and offers suggestions for strategies to fill gaps in our existing scientific knowledge.

Original languageEnglish
Pages (from-to)529-540
Number of pages12
JournalCancer Causes and Control
Issue number4
StatePublished - Apr 2011


  • Breast carcinogenesis
  • Estrogen metabolites
  • Tissue estrogen metabolism


Dive into the research topics of 'Estrogens in the breast tissue: A systematic review'. Together they form a unique fingerprint.

Cite this