@article{95c86c6613ec4229be690b4755d21bd3,
title = "Estrogen-regulated miRNA-27b is altered by bisphenol A in human endometrial stromal cells",
abstract = "MicroRNAs (miRs) are small molecules important for regulation of transcription and translation. The objective was to identify hormonally regulated miRs in human endometrial stromal cells and to determine the impact of the endocrine disruptor, bisphenol A (BPA), on those miRs. miR microarray analysis and multiple confirmatory cell preparations treated with 17β-estradiol (E2) and BPA altered miR-27b, let-7c, let-7e and miR-181b. Further, decidualization downregulated miR-27b. VEGFB and VEGFC were validated as targets of miR-27b. Identification of miR-27b target genes suggests that BPA and E2 downregulate miR-27b thereby leading to upregulation of genes important for vascularization and angiogenesis of the endometrium during the menstrual cycle and decidualization.",
author = "Reed, {Beverly G.} and Babayev, {Samir N.} and Chen, {Lucy X.} and Carr, {Bruce R.} and {Ann Word}, R. and Jimenez, {Patricia T.}",
note = "Funding Information: This work was supported by the Human Biological Fluids Tissue Acquisition Laboratory (NIH P01HD087150) for endometrial specimens. The research was supported by grant K12 HD000849 (P T J), awarded to the Reproductive Scientist Development Program by the Eunice Kennedy Shriver National Institute of Child Health and Human Development and by the Burroughs Wellcome Fund, as part of the Reproductive Scientist Development Program. The authors thank the physicians and staff of Parkland Hospital and Sylvia Wright for tissue procurement. Publisher Copyright: {\textcopyright} 2018 The Authors",
year = "2018",
doi = "10.1530/REP-18-0041",
language = "English",
volume = "156",
pages = "559--567",
journal = "Reproduction",
issn = "1470-1626",
number = "6",
}