Estrogen-like compounds for ischemic neuroprotection

James W. Simpkins, Shao Hua Yang, Ran Liu, Evelyn Perez, Yun Cai Zu, Douglas F. Covey, Pattie S. Green

Research output: Contribution to journalArticlepeer-review

72 Scopus citations


We have synthesized a library of estrogen analogues, including enantiomers of estradiol and A-ring substituted estrogens. These compounds have reduced or no binding to either estrogen receptor-α or estrogen receptor-β, exhibit enhanced neuroprotective activity in in vitro models, and are potent in protecting brain tissue from cerebral ischemia/reperfusion injury. These potent, nonfeminizing estrogen analogues are prime candidates for use in stroke neuroprotection.

Original languageEnglish
Pages (from-to)2648-2651
Number of pages4
Issue number11 SUPPL. 1
StatePublished - Nov 2004


  • Estrogen receptors
  • Estrogens
  • Neuroprotection
  • Stroke


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