Estrogen-like compounds for ischemic neuroprotection

James W. Simpkins; Shao Hua Yang; Ran Liu; Evelyn Perez; Yun Cai Zu; Douglas F. Covey; Pattie S. Green

doi:10.1161/01.STR.0000143734.59507.88

Estrogen-like compounds for ischemic neuroprotection

James W. Simpkins, Shao Hua Yang, Ran Liu, Evelyn Perez, Yun Cai Zu, Douglas F. Covey, Pattie S. Green

Research output: Contribution to journal › Article › peer-review

72 Scopus citations

Abstract

We have synthesized a library of estrogen analogues, including enantiomers of estradiol and A-ring substituted estrogens. These compounds have reduced or no binding to either estrogen receptor-α or estrogen receptor-β, exhibit enhanced neuroprotective activity in in vitro models, and are potent in protecting brain tissue from cerebral ischemia/reperfusion injury. These potent, nonfeminizing estrogen analogues are prime candidates for use in stroke neuroprotection.

Original language	English
Pages (from-to)	2648-2651
Number of pages	4
Journal	Stroke
Volume	35
Issue number	11 SUPPL. 1
DOIs	https://doi.org/10.1161/01.STR.0000143734.59507.88
State	Published - Nov 2004

Keywords

Estrogen receptors
Estrogens
Neuroprotection
Stroke

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10.1161/01.STR.0000143734.59507.88

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AU - Perez, Evelyn

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AU - Covey, Douglas F.

AU - Green, Pattie S.

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KW - Estrogen receptors

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KW - Stroke

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Estrogen-like compounds for ischemic neuroprotection

Abstract

Keywords

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