TY - JOUR
T1 - Estrogen deficiency after menopause does not result in male very-low-density lipoprotein metabolism phenotype
AU - Magkos, Faidon
AU - Fabbrini, Elisa
AU - Mohammed, B. Selma
AU - Patterson, Bruce W.
AU - Klein, Samuel
AU - Mittendorfer, Bettina
N1 - Funding Information:
This work was supported by American Heart Association Grants 0365436Z and 0510015Z and National Institutes of Health Grants AR 49869, DK 37948, HD 057796, DK 56341 (Nutrition Obesity Research Center) , RR 00954 (Biomedical Mass Spectrometry Resource) , RR 00036 (General Clinical Research Center) , and UL1 RR024992 (Institute for Clinical and Translational Science).
PY - 2010/7
Y1 - 2010/7
N2 - Context: Sex differences in lipid metabolism result in a less proatherogenic plasma lipid profile in premenopausal women than men.The mechanisms responsible for this are unclear but are thought to be related to differences in the sex hormone milieu in men and women. Objective: Our objective was to evaluate the effect of endogenous sex hormones on very-lowdensity lipoprotein (VLDL) triglyceride (TG) and apolipoprotein B-100 (apoB-100) metabolism. Experimental Design and Main Outcome Measures: We measured basal VLDL-TG and VLDL-apoB-100 concentrations and kinetics by using stable isotope-labeled tracers. Setting and Participants: Eight premenopausal women [age, 43±8 yr; body mass index (BMI), 35±4 kg/m2; mean ± SD], eight postmenopausal women (age, 55 ± 4 yr; BMI, 34 ± 4 kg/m2), and eight men(age, 41±13 yr; BMI, 34±4 kg/m2) were studied at Washington University School of Medicine, St. Louis, MO. Results: VLDL-TG secretion rate was approximately double (P < 0.05) in postmenopausal women and men compared with premenopausal women but not different in postmenopausal women and men. The secretion rate of VLDL-apoB-100 was not different in pre- and postmenopausal women but was greater (P < 0.05) in men than in women. Conclusions: Endogenous ovarian sex steroids are responsible for sexual dimorphism in VLDL-TG secretion, whereas VLDL-apoB-100 secretion is not regulated by female reproductive hormones.
AB - Context: Sex differences in lipid metabolism result in a less proatherogenic plasma lipid profile in premenopausal women than men.The mechanisms responsible for this are unclear but are thought to be related to differences in the sex hormone milieu in men and women. Objective: Our objective was to evaluate the effect of endogenous sex hormones on very-lowdensity lipoprotein (VLDL) triglyceride (TG) and apolipoprotein B-100 (apoB-100) metabolism. Experimental Design and Main Outcome Measures: We measured basal VLDL-TG and VLDL-apoB-100 concentrations and kinetics by using stable isotope-labeled tracers. Setting and Participants: Eight premenopausal women [age, 43±8 yr; body mass index (BMI), 35±4 kg/m2; mean ± SD], eight postmenopausal women (age, 55 ± 4 yr; BMI, 34 ± 4 kg/m2), and eight men(age, 41±13 yr; BMI, 34±4 kg/m2) were studied at Washington University School of Medicine, St. Louis, MO. Results: VLDL-TG secretion rate was approximately double (P < 0.05) in postmenopausal women and men compared with premenopausal women but not different in postmenopausal women and men. The secretion rate of VLDL-apoB-100 was not different in pre- and postmenopausal women but was greater (P < 0.05) in men than in women. Conclusions: Endogenous ovarian sex steroids are responsible for sexual dimorphism in VLDL-TG secretion, whereas VLDL-apoB-100 secretion is not regulated by female reproductive hormones.
UR - https://www.scopus.com/pages/publications/77954920313
U2 - 10.1210/jc.2010-0341
DO - 10.1210/jc.2010-0341
M3 - Article
C2 - 20444912
AN - SCOPUS:77954920313
SN - 0021-972X
VL - 95
SP - 3377
EP - 3384
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 7
ER -