Loss of estrogen at menopause causes osteoporosis in many women, but estrogen's relevant cellular target in this process has remained unclear. In a recent study in Cell, Kato and colleagues (Nakamura et al., 2007) selectively ablate estrogen receptor α in osteoclasts and demonstrate that estrogen directly induces osteoclast apoptosis.

Original languageEnglish
Pages (from-to)254-256
Number of pages3
JournalCell metabolism
Issue number4
StatePublished - Oct 3 2007


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