Estrogen-2-hydroxylase in the rat. Distribution and response to hormonal manipulation

Andrew R. Huffman, Steven M. Paul, Julius Axelrod

Research output: Contribution to journalArticlepeer-review

79 Scopus citations


Estrogen-2-hydroxylase activity in various rat tissues was surveyed. While the liver, followed by brain, had the highest enzyme activity, nearly all tissues investigated in the male rat possessed 2-hydroxylase activity. Neither the ovary nor the virgin uterus, however, could synthesize 2-hydroxy-estrogens in vitro. Enzyme activities in the male brain and liver were higher than in corresponding female tissues. In the male rat, cytochrome P-450 inducers did not alter brain estrogen-2-hydroxylase activity, but castration caused a fall in enzyme activity in both the brain and liver. Liver estrogen-2-hydroxylase activity was decreased in both hyperthyroid and hypothyroid rats.

Original languageEnglish
Pages (from-to)83-87
Number of pages5
JournalBiochemical Pharmacology
Issue number1
StatePublished - Jan 1 1980


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