TY - JOUR
T1 - Estrogen-2-hydroxylase in the rat. Distribution and response to hormonal manipulation
AU - Huffman, Andrew R.
AU - Paul, Steven M.
AU - Axelrod, Julius
PY - 1980/1/1
Y1 - 1980/1/1
N2 - Estrogen-2-hydroxylase activity in various rat tissues was surveyed. While the liver, followed by brain, had the highest enzyme activity, nearly all tissues investigated in the male rat possessed 2-hydroxylase activity. Neither the ovary nor the virgin uterus, however, could synthesize 2-hydroxy-estrogens in vitro. Enzyme activities in the male brain and liver were higher than in corresponding female tissues. In the male rat, cytochrome P-450 inducers did not alter brain estrogen-2-hydroxylase activity, but castration caused a fall in enzyme activity in both the brain and liver. Liver estrogen-2-hydroxylase activity was decreased in both hyperthyroid and hypothyroid rats.
AB - Estrogen-2-hydroxylase activity in various rat tissues was surveyed. While the liver, followed by brain, had the highest enzyme activity, nearly all tissues investigated in the male rat possessed 2-hydroxylase activity. Neither the ovary nor the virgin uterus, however, could synthesize 2-hydroxy-estrogens in vitro. Enzyme activities in the male brain and liver were higher than in corresponding female tissues. In the male rat, cytochrome P-450 inducers did not alter brain estrogen-2-hydroxylase activity, but castration caused a fall in enzyme activity in both the brain and liver. Liver estrogen-2-hydroxylase activity was decreased in both hyperthyroid and hypothyroid rats.
UR - http://www.scopus.com/inward/record.url?scp=0018920753&partnerID=8YFLogxK
U2 - 10.1016/0006-2952(80)90248-8
DO - 10.1016/0006-2952(80)90248-8
M3 - Article
C2 - 7362627
AN - SCOPUS:0018920753
SN - 0006-2952
VL - 29
SP - 83
EP - 87
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
IS - 1
ER -