Estradiol modulation of α2-noradrenergic receptors in guinea pig brain assessed by tritium-sensitive film autoradiography

Allan E. Johnson, Bruce Nock, Bruce McEwen, Harvey H. Feder

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

In this experiment, we examined the influence of estradiol on α2-noradrenergic receptor binding in the female guinea pig brain with tritium-sensitive film autoradiography. Treatment of ovariectomized guinea pigs with estradiol increased α2-receptor binding in regions of the preoptic area and decreased binding in the ventromedial nucleus of the hypothalamus. There was no effect of estradiol on α2-receptor concentrations in other estradiol concentrating regions or in brain areas which do not concentrate estradiol.

Original languageEnglish
Pages (from-to)153-157
Number of pages5
JournalBrain Research
Volume336
Issue number1
DOIs
StatePublished - Jun 10 1985

Keywords

  • autoradiography
  • estradiol
  • guinea pig
  • lordosis
  • p-aminoclonidine
  • preoptic area
  • ventromedial hypothalamus
  • α-noradrenergic receptors

Fingerprint

Dive into the research topics of 'Estradiol modulation of α2-noradrenergic receptors in guinea pig brain assessed by tritium-sensitive film autoradiography'. Together they form a unique fingerprint.

Cite this