Estimating sex ratio biases in X-linked disorders: Is there an excess of males in families with X-linked ichthyosis?

K. Gladstien, L. J. Shapiro, M. A. Spence

    Research output: Contribution to journalArticlepeer-review

    3 Scopus citations

    Abstract

    We derive the conditional probabilities for estimating the sex ratio in families ascertained through affected males for the study of X-linked recessive diseases. These conditional probabilities correct for the fact that the probability that a family will be ascertained increases with the number of males in the family. Data from four published studies for X-linked ichthyosis vulgaris are analyzed, three having an excess of males and one having a highly statistically significant excess of males. It is not known if this difference in the two samples represents a biological difference between the two populations or an unrecognized ascertainment bias.

    Original languageEnglish
    Pages (from-to)741-746
    Number of pages6
    JournalAmerican journal of human genetics
    Volume31
    Issue number6
    StatePublished - Dec 1 1979

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