TY - GEN
T1 - Estimating electrical conductivity tensors of biological tissues using microelectrode arrays
AU - Gilboa, Elad
AU - La Rosa, Patricio S.
AU - Nehorai, Arye
PY - 2012
Y1 - 2012
N2 - Finding the electrical conductivity of tissue is important for understanding the tissue's structure and functioning. However, the inverse problem of inferring spatial conductivity from data is highly ill-posed and computationally intensive. In this paper, we propose a novel method to solve the inverse problem of inferring tissue conductivity from a set of transmembrane potential and stimuli measurements made by microelectrode arrays (MEA). We propose a parallel optimization algorithm based on a single-step approximation with a parallel alternating optimization routine. This algorithm simplifies the joint tensor field estimation problem into a set of computationally tractable subproblems, allowing the use of efficient standard optimization tools.
AB - Finding the electrical conductivity of tissue is important for understanding the tissue's structure and functioning. However, the inverse problem of inferring spatial conductivity from data is highly ill-posed and computationally intensive. In this paper, we propose a novel method to solve the inverse problem of inferring tissue conductivity from a set of transmembrane potential and stimuli measurements made by microelectrode arrays (MEA). We propose a parallel optimization algorithm based on a single-step approximation with a parallel alternating optimization routine. This algorithm simplifies the joint tensor field estimation problem into a set of computationally tractable subproblems, allowing the use of efficient standard optimization tools.
UR - http://www.scopus.com/inward/record.url?scp=84881067690&partnerID=8YFLogxK
U2 - 10.1109/EMBC.2012.6346112
DO - 10.1109/EMBC.2012.6346112
M3 - Conference contribution
C2 - 23366073
AN - SCOPUS:84881067690
SN - 9781424441198
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 1040
EP - 1044
BT - 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012
T2 - 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012
Y2 - 28 August 2012 through 1 September 2012
ER -