Establishment of normal synaptic density in deafferented olfactory cortex

Beth Friedman; J. L. Price

doi:10.1016/0006-8993(81)90814-3

Establishment of normal synaptic density in deafferented olfactory cortex

Beth Friedman, J. L. Price

Department of Neuroscience

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The piriform cortex has been examined in rats following neonatal deafferentation produced by olfactory bulb removal. The denervated molecular layer of the piriform cortex grows to nearly its full adult thickness and the removed olfactory bulb axons are replaced by intracortical axons. The synaptic density of the molecular layer following this rearrangement is the same as that in the normal cortex.

Original language	English
Pages (from-to)	146-151
Number of pages	6
Journal	Brain Research
Volume	223
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(81)90814-3
State	Published - Oct 26 1981

Keywords

cortical development
deafferentation
neuroplasticity
olfaction
synaptogenesis

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title = "Establishment of normal synaptic density in deafferented olfactory cortex",

abstract = "The piriform cortex has been examined in rats following neonatal deafferentation produced by olfactory bulb removal. The denervated molecular layer of the piriform cortex grows to nearly its full adult thickness and the removed olfactory bulb axons are replaced by intracortical axons. The synaptic density of the molecular layer following this rearrangement is the same as that in the normal cortex.",

keywords = "cortical development, deafferentation, neuroplasticity, olfaction, synaptogenesis",

author = "Beth Friedman and Price, {J. L.}",

note = "Funding Information: We would like to thank Jon Christensen for his expert technical assistance and Sharon Musgrove for typing the publication. This research was supported by NIH Grants NS 15070 and NS 09518.",

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Y1 - 1981/10/26

N2 - The piriform cortex has been examined in rats following neonatal deafferentation produced by olfactory bulb removal. The denervated molecular layer of the piriform cortex grows to nearly its full adult thickness and the removed olfactory bulb axons are replaced by intracortical axons. The synaptic density of the molecular layer following this rearrangement is the same as that in the normal cortex.

AB - The piriform cortex has been examined in rats following neonatal deafferentation produced by olfactory bulb removal. The denervated molecular layer of the piriform cortex grows to nearly its full adult thickness and the removed olfactory bulb axons are replaced by intracortical axons. The synaptic density of the molecular layer following this rearrangement is the same as that in the normal cortex.

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KW - deafferentation

KW - neuroplasticity

KW - olfaction

KW - synaptogenesis

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JO - Brain Research

JF - Brain Research

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Establishment of normal synaptic density in deafferented olfactory cortex

Abstract

Keywords

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