Establishment of a regeneration-specific in vivo bioassay for neurotrophic activity in denervated Ambystoma forelimbs

P. M. Barger; R. A. Tassava

doi:10.1007/BF01950006

Establishment of a regeneration-specific in vivo bioassay for neurotrophic activity in denervated Ambystoma forelimbs

P. M. Barger
, R. A. Tassava

Division of Cardiology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Use of continuous³H-thymidine labeling and subsequent assay for cell cycle activity using a novel parameter, mitotic index of a selectively labeled cell population, has led to the development of a regeneration-specific in vivo bioassay for neurotrophic activity. This system is based on the stimulation of cell cycle arrested cells to resume cycling activity after reinnervation in denervated larval Ambystoma mexicanum forelimb stumps.

Original language	English
Pages (from-to)	1405-1407
Number of pages	3
Journal	Experientia
Volume	41
Issue number	11
DOIs	https://doi.org/10.1007/BF01950006
State	Published - Nov 1985

Keywords

Ambystoma
Regeneration
bioassay
neurotrophic

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10.1007/BF01950006

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title = "Establishment of a regeneration-specific in vivo bioassay for neurotrophic activity in denervated Ambystoma forelimbs",

abstract = "Use of continuous3H-thymidine labeling and subsequent assay for cell cycle activity using a novel parameter, mitotic index of a selectively labeled cell population, has led to the development of a regeneration-specific in vivo bioassay for neurotrophic activity. This system is based on the stimulation of cell cycle arrested cells to resume cycling activity after reinnervation in denervated larval Ambystoma mexicanum forelimb stumps.",

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author = "Barger, \{P. M.\} and Tassava, \{R. A.\}",

year = "1985",

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volume = "41",

pages = "1405--1407",

journal = "Experientia",

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AU - Barger, P. M.

AU - Tassava, R. A.

PY - 1985/11

Y1 - 1985/11

N2 - Use of continuous3H-thymidine labeling and subsequent assay for cell cycle activity using a novel parameter, mitotic index of a selectively labeled cell population, has led to the development of a regeneration-specific in vivo bioassay for neurotrophic activity. This system is based on the stimulation of cell cycle arrested cells to resume cycling activity after reinnervation in denervated larval Ambystoma mexicanum forelimb stumps.

AB - Use of continuous3H-thymidine labeling and subsequent assay for cell cycle activity using a novel parameter, mitotic index of a selectively labeled cell population, has led to the development of a regeneration-specific in vivo bioassay for neurotrophic activity. This system is based on the stimulation of cell cycle arrested cells to resume cycling activity after reinnervation in denervated larval Ambystoma mexicanum forelimb stumps.

KW - Ambystoma

KW - Regeneration

KW - bioassay

KW - neurotrophic

UR - https://www.scopus.com/pages/publications/0022350074

U2 - 10.1007/BF01950006

DO - 10.1007/BF01950006

M3 - Article

AN - SCOPUS:0022350074

SN - 0014-4754

VL - 41

SP - 1405

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JO - Experientia

JF - Experientia

IS - 11

ER -

Establishment of a regeneration-specific in vivo bioassay for neurotrophic activity in denervated Ambystoma forelimbs

Abstract

Keywords

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