Establishment of a regeneration-specific in vivo bioassay for neurotrophic activity in denervated Ambystoma forelimbs

P. M. Barger, R. A. Tassava

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Use of continuous3H-thymidine labeling and subsequent assay for cell cycle activity using a novel parameter, mitotic index of a selectively labeled cell population, has led to the development of a regeneration-specific in vivo bioassay for neurotrophic activity. This system is based on the stimulation of cell cycle arrested cells to resume cycling activity after reinnervation in denervated larval Ambystoma mexicanum forelimb stumps.

Original languageEnglish
Pages (from-to)1405-1407
Number of pages3
JournalExperientia
Volume41
Issue number11
DOIs
StatePublished - Nov 1 1985

Keywords

  • Ambystoma
  • Regeneration
  • bioassay
  • neurotrophic

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