Abstract
Use of continuous3H-thymidine labeling and subsequent assay for cell cycle activity using a novel parameter, mitotic index of a selectively labeled cell population, has led to the development of a regeneration-specific in vivo bioassay for neurotrophic activity. This system is based on the stimulation of cell cycle arrested cells to resume cycling activity after reinnervation in denervated larval Ambystoma mexicanum forelimb stumps.
Original language | English |
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Pages (from-to) | 1405-1407 |
Number of pages | 3 |
Journal | Experientia |
Volume | 41 |
Issue number | 11 |
DOIs | |
State | Published - Nov 1 1985 |
Keywords
- Ambystoma
- Regeneration
- bioassay
- neurotrophic