Establishing the Link between Lean Mass and Grip Strength Cut Points with Mobility Disability and Other Health Outcomes: Proceedings of the Sarcopenia Definition and Outcomes Consortium Conference

Peggy M. Cawthon, Thomas G. Travison, Todd M. Manini, Sheena Patel, Karol M. Pencina, Roger A. Fielding, Jay M. Magaziner, Anne B. Newman, Todd Brown, Douglas P. Kiel, Steve R. Cummings, Michelle Shardell, Jack M. Guralnik, Linda J. Woodhouse, Marco Pahor, Ellen Binder, Ralph B. D'Agostino, Xue Quian-Li, Eric Orwoll, Francesco LandiDenise Orwig, Laura Schaap, Nancy K. Latham, Vasant Hirani, Timothy Kwok, Suzette L. Pereira, Daniel Rooks, Makoto Kashiwa, Moises Torres-Gonzalez, Joseph P. Menetski, Rosaly Correa-De-Araujo, Shalender Bhasin

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Background: Lack of consensus on how to diagnose sarcopenia has limited the ability to diagnose this condition and hindered drug development. The Sarcopenia Definitions and Outcomes Consortium (SDOC) was formed to develop evidence-based diagnostic cut points for lean mass and/or muscle strength that identify people at increased risk of mobility disability. We describe here the proceedings of a meeting of SDOC and other experts to discuss strategic considerations in the development of evidence-based sarcopenia definition. Methods: Presentations and panel discussions reviewed the usefulness of sarcopenia as a biomarker, the analytical approach used by SDOC to establish cut points, and preliminary findings, and provided strategic direction to develop an evidence-based definition of sarcopenia. Results: The SDOC assembled data from eight epidemiological cohorts consisting of 18,831 participants, clinical populations from 10 randomized trials and observational studies, and 2 nationally representative cohorts. In preliminary assessments, grip strength or grip strength divided by body mass index was identified as discriminators of risk for mobility disability (walking speed <0.8 m/s), whereas dual-energy X-ray absorptiometry-derived lean mass measures were not good discriminators of mobility disability. Candidate definitions based on grip strength variables were associated with increased risk of mortality, falls, mobility disability, and instrumental activities of daily living disability. The prevalence of low grip strength increased with age. The attendees recommended the establishment of an International Expert Panel to review a series of position statements on sarcopenia definition that are informed by the findings of the SDOC analyses and synthesis of literature. Conclusions: International consensus on an evidence-based definition of sarcopenia is needed. Grip strength - absolute or adjusted for body mass index - is an important discriminator of mobility disability and other endpoints. Additional research is needed to develop a predictive risk model that takes into account sarcopenia components as well as age, sex, race, and comorbidities.

Original languageEnglish
Pages (from-to)1317-1323
Number of pages7
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume75
Issue number7
DOIs
StatePublished - Jul 2020

Keywords

  • Grip strength cut-points
  • Lean mass cut-points
  • Mobility disability
  • Risk factors for mobility disability
  • Sarcopenia

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