TY - JOUR
T1 - Establishing a Framework for Gathering Structural and Social Determinants of Health in Alzheimer's Disease Research Centers
AU - Stites, Shana D.
AU - Midgett, Sharnita
AU - Mechanic-Hamilton, Dawn
AU - Zuelsdorff, Megan
AU - Glover, Crystal M.
AU - Marquez, David X.
AU - Balls-Berry, Joyce E.
AU - Streitz, Marissa L.
AU - Babulal, Ganesh
AU - Trani, Jean Francois
AU - Neil Henderson, J.
AU - Barnes, Lisa L.
AU - Karlawish, Jason
AU - Wolk, Dave A.
N1 - Publisher Copyright:
© 2021 The Author(s) 2021
PY - 2022/6/1
Y1 - 2022/6/1
N2 - Structural and social determinants of health (SSDoH) are environmental conditions in which individuals are born, live, learn, work, play, worship, and age that affect health, functioning, and quality-of-life outcomes across the life course. Growing evidence suggests that SSDoH can help to explain heterogeneity in outcomes in Alzheimer's disease and Alzheimer's disease and related dementias (AD/ADRD) research and clinical practice. The National Institute on Aging has prioritized collecting SSDoH data to elucidate disease mechanisms and aid discovery of disease-modifying treatments. However, a major nexus of AD/ADRD research, the national network of Alzheimer's Disease Research Centers (ADRCs), collects few SSDoH data. We describe a framework for feasibly gathering and modeling SSDoH data across ADRCs. We lay out key constructs, their measures, and empirical evidence for their importance in elucidating disease and prevention mechanisms. Toward a goal of translation, the framework proposes a modular structure with a core set of measures and options for adjunctive modules. We describe considerations for measuring SSDoH in existing geographically and culturally diverse research cohorts. We also outline a rationale for universal implementation of a set of SSDoH measures and juxtapose the approach with alternatives aimed at collecting SSDoH data.
AB - Structural and social determinants of health (SSDoH) are environmental conditions in which individuals are born, live, learn, work, play, worship, and age that affect health, functioning, and quality-of-life outcomes across the life course. Growing evidence suggests that SSDoH can help to explain heterogeneity in outcomes in Alzheimer's disease and Alzheimer's disease and related dementias (AD/ADRD) research and clinical practice. The National Institute on Aging has prioritized collecting SSDoH data to elucidate disease mechanisms and aid discovery of disease-modifying treatments. However, a major nexus of AD/ADRD research, the national network of Alzheimer's Disease Research Centers (ADRCs), collects few SSDoH data. We describe a framework for feasibly gathering and modeling SSDoH data across ADRCs. We lay out key constructs, their measures, and empirical evidence for their importance in elucidating disease and prevention mechanisms. Toward a goal of translation, the framework proposes a modular structure with a core set of measures and options for adjunctive modules. We describe considerations for measuring SSDoH in existing geographically and culturally diverse research cohorts. We also outline a rationale for universal implementation of a set of SSDoH measures and juxtapose the approach with alternatives aimed at collecting SSDoH data.
KW - Alzheimer's
KW - Measurement
KW - SSDOH
KW - Social determinants of health
UR - http://www.scopus.com/inward/record.url?scp=85131225452&partnerID=8YFLogxK
U2 - 10.1093/geront/gnab182
DO - 10.1093/geront/gnab182
M3 - Article
C2 - 34919705
AN - SCOPUS:85131225452
SN - 0016-9013
VL - 62
SP - 694
EP - 703
JO - Gerontologist
JF - Gerontologist
IS - 5
ER -